子宫内病毒感染伴发的疾病。母体抗体在经胎盘感染淋巴细胞性脉络丛脑膜炎病毒后组织损伤中的作用。
Disease accompanying in utero viral infection. The role of maternal antibody in tissue injury after transplacental infection with lymphocytic choriomeningitis virus.
作者信息
Oldstone M B, Dixon F J
出版信息
J Exp Med. 1972 Apr 1;135(4):827-38. doi: 10.1084/jem.135.4.827.
Abstract
Early, after in utero infection with LCM virus, SWR/J and HA/ICR mice developed manifestations of immune complex disease. Observations based on nursing such mice with virus-infected, immune, or noninfected mouse mothers indicated that maternal antiviral antibody was responsible for the early immune complex glomerulonephritis. Despite comparable viral persistance, in utero-infected offspring failed to develop glomerulonephritis when nursed by noninfected mouse mothers, but did when suckled by virus-infected mouse mothers. Nursing by mouse mothers carrying high titers of anti-LCM viral antibody markedly enhanced the Ig glomerular deposits and the resultant nephritis.
摘要
在子宫内感染淋巴细胞性脉络丛脑膜炎病毒（LCM病毒）后，SWR/J和HA/ICR小鼠早期出现了免疫复合物疾病的表现。基于用感染病毒、免疫或未感染的母鼠哺育此类小鼠的观察表明，母源抗病毒抗体是早期免疫复合物性肾小球肾炎的病因。尽管病毒持续存在情况相似，但子宫内感染的子代由未感染的母鼠哺育时未发生肾小球肾炎，而由感染病毒的母鼠哺育时则会发生。携带高滴度抗LCM病毒抗体的母鼠哺育会显著增强肾小球Ig沉积及由此产生的肾炎。
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