Hoffsten P E, Dixon F J
J Exp Med. 1973 Oct 1;138(4):887-99. doi: 10.1084/jem.138.4.887.
C3H mice chronically infected with LCM virus were found to be lethally affected by small doses of immunosuppression which caused bone marrow aplasia but had no effect on the amount of virus carried by the mouse. Humoral immune response of SWR/J mice to acute LCM infection was found to be totally suppressed by repeated single doses of 300 R/wk with no alteration in the level of virus carried by the mouse. In contrast, the established anti-LCM humoral immune response encountered in mice chronically infected with LCM virus was not suppressed by the same irradiation procedure. Over half of the chronic LCM carrier SWR/J mice treated with cyclophosphamide for 6 mo had total anti-LCM humoral immunosuppression, but showed no change in the level of virus carried. The glomerulonephritis which occurs in chronic LCM carrier mice was prevented by cyclophosphamide treatment in 90% of the mice. The humoral immune response which occurs in chronic LCM carrier mice appears to play no role in controlling the amount of virus carried by the mouse. Suppression of the LCM immune response by cyclophosphamide does prevent the development of glomerulonephritis in these mice.
发现长期感染淋巴细胞性脉络丛脑膜炎病毒（LCM病毒）的C3H小鼠会受到小剂量免疫抑制的致命影响，这种免疫抑制会导致骨髓再生障碍，但对小鼠携带的病毒量没有影响。发现SWR/J小鼠对急性LCM感染的体液免疫反应会被每周300拉德的重复单次剂量完全抑制，而小鼠携带的病毒水平没有改变。相比之下，长期感染LCM病毒的小鼠中已建立的抗LCM体液免疫反应不会被相同的照射程序抑制。用环磷酰胺治疗6个月的慢性LCM携带者SWR/J小鼠中，超过一半出现了完全的抗LCM体液免疫抑制，但携带的病毒水平没有变化。环磷酰胺治疗可使90%的慢性LCM携带者小鼠预防肾小球肾炎的发生。慢性LCM携带者小鼠中出现的体液免疫反应似乎在控制小鼠携带的病毒量方面不起作用。环磷酰胺对LCM免疫反应的抑制确实可防止这些小鼠发生肾小球肾炎。
