Cabalum T, Zugaib M, Lieb S, Nuwayhid B, Brinkman C R, Assali N S
Am J Obstet Gynecol. 1979 Mar 15;133(6):630-4. doi: 10.1016/0002-9378(79)90009-7.
Chronically instrumented, near-term pregnant sheep were subjected to autonomic blockade with spinal anesthesia. Systemic arterial pressure, heart rate, and uterine blood flow decreased and uterine vascular resistance increased during the spinal blockade. Infusion of dopamine during the spinal hypotension corrected the disturbed circulatory parameters. These data provide evidence that: (1) the peripheral circulation of the near-term pregnant sheep is as sensitive as that of pregnant women to autonomic blockade, (2) the sensitivity is probably related to factors other than the changes in venous pressure in areas below the pelvis, and (3) dopamine represents a useful agent in the management of spinal hypotension.
对长期植入仪器的近足月妊娠绵羊进行脊髓麻醉以实现自主神经阻滞。在脊髓阻滞期间，全身动脉压、心率和子宫血流量降低，子宫血管阻力增加。在脊髓性低血压期间输注多巴胺可纠正紊乱的循环参数。这些数据表明：（1）近足月妊娠绵羊的外周循环对自主神经阻滞的敏感性与孕妇相同；（2）这种敏感性可能与骨盆以下区域静脉压变化以外的因素有关；（3）多巴胺是治疗脊髓性低血压的有效药物。
