Zugaib M, Nuwayhid B S, Vaughn D L, Brinkman C R, Assali N S
Surg Gynecol Obstet. 1979 Sep;149(3):337-42.
The cardiovascular effects of endotoxin in the unanesthetized chronically instrumented sheep were investigated. The observations were extended to include the response to intravenous infusions of dopamine to the same sheep at the height of endotoxin action. When the cardiovascular effects of endotoxin in the unanesthetized and anesthetized sheep were compared, there were distinct differences. Unanesthetized sheep tolerated considerably greater dosages of endotoxin. In anesthetized sheep, the compensatory stimulation of the sympathoadrenal system seems to have been blunted and all of the circulatory parameters deteriorate rapidly, ending in death within three hours. In the absence of anesthesia, there was clear evidence of a compensatory sympathoadrenal stimulation, as reflected by the return of most of the circulatory parameters to normal values, and furthermore, the sheep recovered from the effects of endotoxin. The exact mechanism by which anesthesia altered the response of the sheep to endotoxin was not clear. Depression of the baroreceptor and neurohumoral compensatory mechanisms was suggested. The present data indicated that dopamine was a useful agent in correcting the cardiovascular changes brought about by endotoxin.
研究了内毒素对未麻醉的、长期植入仪器的绵羊的心血管效应。观察范围扩大到包括在内毒素作用最强时，对同一批绵羊静脉输注多巴胺的反应。当比较内毒素对未麻醉绵羊和麻醉绵羊的心血管效应时，发现了明显差异。未麻醉的绵羊能耐受相当大剂量的内毒素。在麻醉的绵羊中，交感肾上腺系统的代偿性刺激似乎受到了抑制，所有循环参数迅速恶化，在三小时内死亡。在没有麻醉的情况下，有明确证据表明存在代偿性交感肾上腺刺激，这表现为大多数循环参数恢复到正常水平，此外，绵羊从内毒素的影响中恢复过来。麻醉改变绵羊对内毒素反应的确切机制尚不清楚。有人提出是压力感受器和神经体液代偿机制受到了抑制。目前的数据表明，多巴胺是纠正内毒素引起的心血管变化的有效药物。
