Neu H C, Aswapokee N, Aswapokee P, Fu K P
Antimicrob Agents Chemother. 1979 Feb;15(2):273-81. doi: 10.1128/AAC.15.2.273.
The in vitro activity of HR 756, 7-[2-(2-amino-4-thiazolyl)-2-(Z)-(methoximino)acetamido] cephalosporanic acid, was investigated against 659 isolates. HR 756 inhibited Neisseria and Haemophilus species at concentrations similar to those needed with ampicillin. It inhibited beta-lactamase-producing N. gonorrhoeae and H. influenzae. HR 756 was the most active compound tested against members of the Enterobacteriaceae, inhibiting most isolates of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella, Enterobacter, and Shigella at concentrations of less than 0.1 mug/ml. It was twice as active as carbenicillin against Pseudomonas aeruginosa and inhibited Bacteroides fragilis as well as cefoxitin. HR 756 killed E. coli, Staphylococcus aureus, and P. aeruginosa at rates similar to other beta-lactam antibiotics.
对659株分离菌研究了HR 756（7-[2-(2-氨基-4-噻唑基)-2-(Z)-(甲氧基亚氨基)乙酰胺基]头孢烷酸）的体外活性。HR 756抑制奈瑟菌属和嗜血杆菌属的浓度与氨苄西林所需浓度相似。它能抑制产β-内酰胺酶的淋病奈瑟菌和流感嗜血杆菌。HR 756是所测试的对肠杆菌科细菌最具活性的化合物，在浓度低于0.1μg/ml时可抑制大多数大肠杆菌、肺炎克雷伯菌、奇异变形杆菌、沙门菌属、肠杆菌属和志贺菌属的分离菌。它对铜绿假单胞菌的活性是羧苄西林的两倍，并且能抑制脆弱拟杆菌以及头孢西丁。HR 756杀灭大肠杆菌、金黄色葡萄球菌和铜绿假单胞菌的速率与其他β-内酰胺类抗生素相似。
