HR 756，一种对革兰氏阳性菌及革兰氏阴性需氧菌和厌氧菌均有活性的新型头孢菌素。
HR 756, a new cephalosporin active against gram-positive and gram-negative aerobic and anaerobic bacteria.
作者信息
Neu H C, Aswapokee N, Aswapokee P, Fu K P
出版信息
Antimicrob Agents Chemother. 1979 Feb;15(2):273-81. doi: 10.1128/AAC.15.2.273.
Abstract
The in vitro activity of HR 756, 7-[2-(2-amino-4-thiazolyl)-2-(Z)-(methoximino)acetamido] cephalosporanic acid, was investigated against 659 isolates. HR 756 inhibited Neisseria and Haemophilus species at concentrations similar to those needed with ampicillin. It inhibited beta-lactamase-producing N. gonorrhoeae and H. influenzae. HR 756 was the most active compound tested against members of the Enterobacteriaceae, inhibiting most isolates of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella, Enterobacter, and Shigella at concentrations of less than 0.1 mug/ml. It was twice as active as carbenicillin against Pseudomonas aeruginosa and inhibited Bacteroides fragilis as well as cefoxitin. HR 756 killed E. coli, Staphylococcus aureus, and P. aeruginosa at rates similar to other beta-lactam antibiotics.
摘要
对659株分离菌研究了HR 756（7-[2-(2-氨基-4-噻唑基)-2-(Z)-(甲氧基亚氨基)乙酰胺基]头孢烷酸）的体外活性。HR 756抑制奈瑟菌属和嗜血杆菌属的浓度与氨苄西林所需浓度相似。它能抑制产β-内酰胺酶的淋病奈瑟菌和流感嗜血杆菌。HR 756是所测试的对肠杆菌科细菌最具活性的化合物，在浓度低于0.1μg/ml时可抑制大多数大肠杆菌、肺炎克雷伯菌、奇异变形杆菌、沙门菌属、肠杆菌属和志贺菌属的分离菌。它对铜绿假单胞菌的活性是羧苄西林的两倍，并且能抑制脆弱拟杆菌以及头孢西丁。HR 756杀灭大肠杆菌、金黄色葡萄球菌和铜绿假单胞菌的速率与其他β-内酰胺类抗生素相似。
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本文引用的文献
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Cefamandole, a cephalosporin antibiotic with an unusually wide spectrum of activity.头孢孟多，一种具有异常广泛活性谱的头孢菌素抗生素。
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Cefoxitin, a semisynthetic cephamycin antibiotic: antibacterial spectrum and resistance to hydrolysis by gram-negative beta-lactamases.头孢西丁，一种半合成头孢霉素抗生素：抗菌谱及对革兰氏阴性β-内酰胺酶水解的抗性。
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The beta-lactamases of gram-negative bacteria and their possible physiological role.革兰氏阴性菌的β-内酰胺酶及其可能的生理作用。
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Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.一种使用显色头孢菌素底物检测β-内酰胺酶的新方法。
Antimicrob Agents Chemother. 1972 Apr;1(4):283-8. doi: 10.1128/AAC.1.4.283.
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Mecillinam, a novel penicillanic acid derivative with unusual activity against gram-negative bacteria.美西林，一种新型青霉素酸衍生物，对革兰氏阴性菌具有独特活性。
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Cefuroxime - a new cephalosporin antibiotic.头孢呋辛——一种新型头孢菌素类抗生素。
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Cefoxitin resistance to beta-lactamase: a major factor for susceptibility of bacteroides fragilis to the antibiotic.头孢西丁对β-内酰胺酶的耐药性：脆弱拟杆菌对抗生素敏感性的一个主要因素。
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