人冷冻保存甲状旁腺组织的自体移植
Autotransplantation of cryopreserved parathyroid tissue in man.
作者信息
Brennan M F, Brown E M, Spiegel A M, Marx S J, Doppman J L, Jones D C, Aurbach G D
出版信息
Ann Surg. 1979 Feb;189(2):139-42. doi: 10.1097/00000658-197902000-00002.
Abstract
Human cryopreserved parathyroid autografts have been performed in six patients following reoperative parathyroid surgery. All patients were rendered hypoparathyroid by their most recent reoperation. Parathyroid tissue was successfully autotransplanted after as long as eighteen months of cryopreservation. Viability and expected in vivo function of cryopreserved parathyroid tissue may be predicted by in vitro testing of parathyroid hormone secretion in response to varying ambient calcium concentration. Parathyroid cryopreservation with subsequent autotransplantation is a practical solution to the problem of permanent hypoparathyroidism that may follow multiple surgical procedures for persistent hyperparathyroidism.
摘要
六例患者在再次进行甲状旁腺手术后接受了人冷冻保存甲状旁腺自体移植。所有患者在最近一次再次手术后均出现甲状旁腺功能减退。甲状旁腺组织在冷冻保存长达18个月后成功进行了自体移植。通过体外检测甲状旁腺激素在不同环境钙浓度下的分泌情况，可以预测冷冻保存甲状旁腺组织的活力和预期的体内功能。甲状旁腺冷冻保存及随后的自体移植是解决因多次手术治疗持续性甲状旁腺功能亢进可能导致的永久性甲状旁腺功能减退问题的一种切实可行的方法。
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