同种异体移植的甲状旁腺：免疫抑制宿主中功能的评估。

The allografted parathyroid gland: evaluation of function in the immunosuppressed host.

作者信息

Wells S A, Burdick J F, Hattler B G, Christiansen C, Pettigrew H M, Abe M, Sherwood L M

出版信息

Ann Surg. 1974 Dec;180(6):805-13. doi: 10.1097/00000658-197412000-00001.

DOI:10.1097/00000658-197412000-00001

PMID:4279632

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1343799/

Abstract

Parathyroid autografts were performed in 19 random bred mongrels and parathyroid allografts were exchanged between seven random bred mongrels. Three pairs of siblings from a beagle colony were immunosuppressed and parathyroid allografts exchanged between them. The parathyroid autografts were successful, while parathyroid allografts failed on all occasions in the non-immunosuppressed host. In immunosuppressed animals, however, the allografts were successful in five of six dogs. The success of parathyroid transplantation was determined by the following observations: 1) The experimental animal, having grafted parathyroid tissue as the only source of hormone, maintained a normal or near normal serum calcium concentration. 2) Following removal of the parathyroid graft, there was an immediate fall in the serum calcium concentration associated with tetany and/or death. 3) Histological study of the grafted gland revealed normal architecture, and 4) Radioimmunoassay of extracted grafts revealed moderate to large quantities of parathyroid hormone.

摘要

对19只随机繁殖的杂种犬进行了甲状旁腺自体移植，并在7只随机繁殖的杂种犬之间进行了甲状旁腺同种异体移植。对来自一个小猎犬群体的3对同胞犬进行免疫抑制，并在它们之间进行甲状旁腺同种异体移植。甲状旁腺自体移植成功，而在未免疫抑制的宿主中，甲状旁腺同种异体移植在所有情况下均失败。然而，在免疫抑制的动物中，6只犬中有5只的同种异体移植成功。甲状旁腺移植的成功通过以下观察来确定：1）作为唯一激素来源移植了甲状旁腺组织的实验动物，血清钙浓度维持正常或接近正常。2）切除甲状旁腺移植物后，血清钙浓度立即下降，并伴有手足搐搦和/或死亡。3）移植腺体的组织学研究显示结构正常，4）对提取移植物的放射免疫分析显示有中等至大量的甲状旁腺激素。