犬红细胞。体内密度的调节。
Dog red blood cells. Adjustment of density in vivo.
作者信息
Parker J C
出版信息
J Gen Physiol. 1973 Feb;61(2):146-57. doi: 10.1085/jgp.61.2.146.
Abstract
Red blood cells from mature dogs contain less Na and more K than would be the case if they were in Donnan equilibrium with plasma. They have no ouabain-sensitive Na pump, and their membranes are deficient in Na, K-ATPase. Experiments are reported in which dog red cells were first loaded with supranormal quantities of Na and water and then reinjected into the dog. Over the course of 26-40 h the Na- and water-loaded cells returned to a normal state of hydration as judged by their density. It is concluded that dog red cells possess some means of correcting their swollen status in vivo, despite their lack of a ouabain-sensitive cation transport apparatus.
摘要
成熟犬的红细胞所含的钠比处于与血浆的唐南平衡时少，而钾则更多。它们没有哇巴因敏感的钠泵，其细胞膜中缺乏钠钾ATP酶。本文报道了一些实验，其中先给犬红细胞加载超量的钠和水，然后再将其重新注入犬体内。在26 - 40小时的过程中，通过密度判断，加载了钠和水的细胞恢复到了正常的水合状态。得出的结论是，尽管犬红细胞缺乏哇巴因敏感的阳离子转运机制，但它们在体内拥有某种纠正肿胀状态的方法。
相似文献
1
Dog red blood cells. Adjustment of density in vivo.犬红细胞。体内密度的调节。
J Gen Physiol. 1973 Feb;61(2):146-57. doi: 10.1085/jgp.61.2.146.
2
Cell volume-sensitive Na+-ATPase activity in rat kidney cortex cell membranes.大鼠肾皮质细胞膜中细胞体积敏感性钠-ATP酶活性
Biochim Biophys Acta. 1988 Jun 7;941(1):107-10. doi: 10.1016/0005-2736(88)90219-2.
3
Membrane ATP and the functional organization of the red cell Na:K pump.膜ATP与红细胞钠钾泵的功能组织
Ann N Y Acad Sci. 1974;242(0):459-60. doi: 10.1111/j.1749-6632.1974.tb19109.x.
4
Several cation transporters and volume regulation in high-K dog red blood cells.高钾犬红细胞中的几种阳离子转运体与容积调节
Am J Physiol. 1991 Mar;260(3 Pt 1):C589-97. doi: 10.1152/ajpcell.1991.260.3.C589.
5
Evolution of the branchial sodium outflux and its components, especially the Na-K exchange and the Na-K dependent ATPase activity during adaptation to sea water in Anguilla anguilla.欧洲鳗鲡适应海水过程中鳃部钠外流及其组分的演变，尤其是钠钾交换和钠钾依赖的ATP酶活性。
Comp Biochem Physiol A Comp Physiol. 1972 Nov 1;43(3):577-91. doi: 10.1016/0300-9629(72)90245-9.
6
Partial purification of the ouabain-binding component and of Na,K-ATPase from human red cell membranes.从人红细胞膜中对哇巴因结合成分和钠钾ATP酶进行部分纯化。
Proc Natl Acad Sci U S A. 1970 Jul;66(3):936-43. doi: 10.1073/pnas.66.3.936.
7
8
Dog red blood cells. Adjustment of salt and water content in vitro.犬红细胞。体外盐和水含量的调节。
J Gen Physiol. 1973 Aug;62(2):147-56. doi: 10.1085/jgp.62.2.147.
9
Sodium movements in the human red blood cell.人体红细胞中的钠运动。
J Gen Physiol. 1970 Sep;56(3):322-41. doi: 10.1085/jgp.56.3.322.
10
Changes of sodium transport in erythrocytes of the maturing rabbit.成熟兔红细胞中钠转运的变化
Am J Physiol. 1975 Feb;228(2):461-4. doi: 10.1152/ajplegacy.1975.228.2.461.
引用本文的文献
1
Evolution of our understanding of cell volume regulation by the pump-leak mechanism.泵漏机制对细胞体积调节的认识演变。
J Gen Physiol. 2019 Apr 1;151(4):407-416. doi: 10.1085/jgp.201812274. Epub 2019 Feb 19.
2
Effects of amrinone, a cardiotonic drug, on calcium movements in dog erythrocytes.强心药氨力农对犬红细胞钙转运的影响。
J Clin Invest. 1980 Aug;66(2):254-9. doi: 10.1172/JCI109851.
3
Study of maturation of membrane transport function in red blood cells by X-ray microanalysis.
J Membr Biol. 1982;67(2):103-11. doi: 10.1007/BF01868653.
4
Cell volume regulation by Amphiuma red blood cells. The role of Ca+2 as a modulator of alkali metal/H+ exchange.美西螈红细胞的细胞体积调节。钙离子作为碱金属/氢离子交换调节剂的作用。
J Gen Physiol. 1983 Dec;82(6):761-84. doi: 10.1085/jgp.82.6.761.
5
Sodium- and adenosine-triphosphate-dependent calcium movements in membrane vesicles prepared from dog erythrocytes.从犬红细胞制备的膜囊泡中钠和三磷酸腺苷依赖的钙转运
J Physiol. 1984 Sep;354:287-301. doi: 10.1113/jphysiol.1984.sp015376.
6
Dog red blood cells. Adjustment of salt and water content in vitro.犬红细胞。体外盐和水含量的调节。
J Gen Physiol. 1973 Aug;62(2):147-56. doi: 10.1085/jgp.62.2.147.
7
Functional separation of the Na-K exchange pump from the volume controlling mechanism in enlarged duck red cells.在增大的鸭红细胞中钠钾交换泵与容积控制机制的功能分离。
J Gen Physiol. 1974 Oct;64(4):393-412. doi: 10.1085/jgp.64.4.393.
8
Measurement of a wide range of intracellular sodium concentrations in erythrocytes by 23Na nuclear magnetic resonance.通过23Na核磁共振测量红细胞内广泛范围内的钠浓度。
Biophys J. 1985 Apr;47(4):553-61. doi: 10.1016/S0006-3495(85)83950-3.
9
Sodium permeability of dog red blood cell membranes. I. Identification of regulatory sites.犬红细胞膜的钠通透性。I. 调节位点的鉴定。
J Gen Physiol. 1976 May;67(5):563-78. doi: 10.1085/jgp.67.5.563.
10
Volume regulation by flounder red blood cells in anisotonic media.比目鱼红细胞在非等渗介质中的体积调节
J Gen Physiol. 1977 May;69(5):537-52. doi: 10.1085/jgp.69.5.537.
本文引用的文献
1
The haemolytic action of potassium salts.钾盐的溶血作用。
J Physiol. 1942 Nov 30;101(3):265-83. doi: 10.1113/jphysiol.1942.sp003981.
2
DETERMINATION OF DENSITY DISTRIBUTION OF RED CELL POPULATION.红细胞群体密度分布的测定
J Lab Clin Med. 1964 Oct;64:668-74.
3
SPECIES DIFFERENCES IN THE EFFECT OF SODIUM AND POTASSIUM IONS ON THE ATPASE OF ERYTHROCYTE MEMBRANES.钠和钾离子对红细胞膜ATP酶作用的种属差异
Biochim Biophys Acta. 1964 Mar 30;79:424-6.
4
FAILURE TO FIND INCREASED SODIUM, POTASSIUM-ATPASE IN RED CELL GHOSTS OF SCHIZOPHRENICS.在精神分裂症患者的红细胞影中未发现钠钾ATP酶增加。
Nature. 1964 Feb 22;201:823. doi: 10.1038/201823a0.
5
Regulation of cell volume by active cation transport in high and low potassium sheep red cells.高钾和低钾绵羊红细胞中通过主动阳离子转运调节细胞体积
J Gen Physiol. 1960 Sep;44(1):169-94. doi: 10.1085/jgp.44.1.169.
6
Red cell survival in the dog determined by a method of differential agglutination employing canine anti-A serum.采用犬抗A血清通过差异凝集法测定犬的红细胞存活率。
J Lab Clin Med. 1956 Jan;47(1):83-7.
7
Potassium and sodium balance in mammalian red cells.哺乳动物红细胞中的钾钠平衡。
Science. 1954 Sep 17;120(3116):459-60. doi: 10.1126/science.120.3116.459.
8
High resolution autoradiography with 51Cr.使用51铬的高分辨率放射自显影术。
Int J Appl Radiat Isot. 1969 Jun;20(6):471-3. doi: 10.1016/0020-708x(69)90139-2.
9
Ouabain-insensitive effects of metabolism on ion and water content of red blood cells.哇巴因不敏感的代谢对红细胞离子和水含量的影响。
Am J Physiol. 1971 Jul;221(1):338-42. doi: 10.1152/ajplegacy.1971.221.1.338.
10
Cellular inhomogeneity in dog red cells as revealed by sodium flux.通过钠通量揭示的犬红细胞中的细胞不均一性。
J Gen Physiol. 1970 Oct;56(4):438-61. doi: 10.1085/jgp.56.4.438.
Zotero 插件