Lampert P W, Oldstone M B
Science. 1973 Apr 27;180(4084):408-10. doi: 10.1126/science.180.4084.408.
Hybrid (NZB x W)F(1) mice spontaneously develop antibodies to nuclear antigens (ANA) and DNA (ADNA) and are an animal model of human systemic lupus erythematosus. Immunofluorescent and electron microscopic observations of the choroid plexus and renal glomeruli of (NZB x W)F(1) mice reveal deposits of host immunoglobulin G (IgG) and the third complement component which appear shortly after the development of ANA and ADNA in the circulation. Additionally, enhancement of ADNA responses accelerates the appearance and severity of IgG deposits in the choroid plexus. The choroid plexus may be a favored site for the deposition of immune complexes and the neuropsychiatric findings in patients with systemic lupus erythematosus and some patients with acute or chronic infections may be related in part to immune complex disease of the choroid plexus.
杂交（新西兰黑鼠×新西兰白鼠）F(1)小鼠会自发产生针对核抗原（ANA）和DNA（ADNA）的抗体，是人类系统性红斑狼疮的动物模型。对（新西兰黑鼠×新西兰白鼠）F(1)小鼠脉络丛和肾小球的免疫荧光及电子显微镜观察显示，在循环中出现ANA和ADNA后不久，就会出现宿主免疫球蛋白G（IgG）和第三补体成分的沉积。此外，ADNA反应的增强会加速脉络丛中IgG沉积的出现和严重程度。脉络丛可能是免疫复合物沉积的有利部位，系统性红斑狼疮患者以及一些急性或慢性感染患者的神经精神症状可能部分与脉络丛的免疫复合物疾病有关。
