Brentjens J, Ossi E, Albini B, Sepulveda M, Kano K, Sheffer J, Vasilion P, Marine E, Baliah T, Jockin H, Andres G
Arthritis Rheum. 1977 May;20(4):962-8. doi: 10.1002/art.1780200408.
Immunohistologic studies were performed on autopsy tissues of 2 patients with systemic lupus erythematosus. All tissues examined--the kidney, lung, spleen, liver, intestine, peritoneum, and choroid plexus--contained immune deposits. Antinuclear antibody concentration in immunoglobulin G eluted from lung and spleen tissue was higher than in serum immunoglobulin G. These findings support the assumption that in systemic lupus erythematosus the renal as well as the extrarenal lesions can be attributed to vascular deposition of immune complexes.
对2例系统性红斑狼疮患者的尸检组织进行了免疫组织学研究。所有检查的组织——肾脏、肺、脾脏、肝脏、肠道、腹膜和脉络丛——均含有免疫沉积物。从肺和脾脏组织洗脱的免疫球蛋白G中的抗核抗体浓度高于血清免疫球蛋白G。这些发现支持了以下假设：在系统性红斑狼疮中，肾脏以及肾外病变可归因于免疫复合物的血管沉积。
