Kelling C L, Schipper I A, Haugse C N
Can J Comp Med. 1973 Jul;37(3):309-12.
The serum antibody response of calves vaccinated against infectious bovine rhinotracheitis by the intramuscular route was compared to calves vaccinated subcutaneously. Immunological response in the calves as determined by serum neutralization tests was highly variable; however, a significantly greater percentage (87.5%) of the calves inoculated subcutaneously responded to vaccination by producing a four-week post-vaccinal serum titer of two or higher as compared to only 47.8% of the calves that were vaccinated intramuscularly. Of those calves that were vaccinated a second time, all maintained or had produced titers of two or higher within four weeks after the second immunization. However, the existing circulating serum antibody titers resulting from the first vaccination of nine of 22 calves were lowered by repeat vaccination.
将通过肌肉注射途径接种传染性牛鼻气管炎疫苗的犊牛的血清抗体反应，与皮下接种疫苗的犊牛进行了比较。通过血清中和试验确定的犊牛免疫反应高度可变；然而，与仅47.8%的肌肉注射疫苗的犊牛相比，皮下接种疫苗的犊牛中有显著更高比例（87.5%）在接种疫苗四周后产生的血清滴度为2或更高，从而对疫苗接种产生反应。在那些第二次接种疫苗的犊牛中，所有犊牛在第二次免疫后四周内维持或产生了2或更高的滴度。然而，22头犊牛中有9头因首次接种疫苗产生的现有循环血清抗体滴度因重复接种而降低。
