前列腺素在新生儿肾素 - 血管紧张素 - 醛固酮系统功能亢进中的可能作用。
The possible role of prostaglandins in the hyperfunction of the renin-angiotensin-aldosterone system in the newborn.
作者信息
Sulyok E, Németh M, Tényi I, Csaba I F, Thurzó V, Hadnagy J
出版信息
Br J Obstet Gynaecol. 1979 Mar;86(3):205-9. doi: 10.1111/j.1471-0528.1979.tb10594.x.
Plasma renin activity and plasma aldosterone concentration were measured by radioimmunoassay in eight newborn infants born vaginally to mothers on indomethacin treatment. Measurements were made in venous cord blood at birth and on the sixth day of life. The results were compared to those obtained in eight healthy control newborn infants of similar gestational age and birth weight. Maternal treatment with indomethacin was associated with a decrease of plasma renin activity (mean +/- SD) from 16.71 +/- 2.76 ng/ml/hour in the control group to 9.60 +/- 3.84 ng/ml/hour in the treated group. Plasma aldosterone concentration was lower in the cord blood of the treated group and a similar trend was demonstrated in the sixth day samples. It is suggested that the increased endogenous prostaglandin production during labour may be one of the factors responsible for the development of hyperactivity of renin-angiotensin-aldosterone system in the newborn.
采用放射免疫分析法对8例母亲接受吲哚美辛治疗的经阴道分娩的新生儿进行血浆肾素活性和血浆醛固酮浓度测定。分别于出生时及出生后第6天采集脐静脉血进行检测。将结果与8例胎龄和出生体重相似的健康对照新生儿的结果进行比较。母亲接受吲哚美辛治疗与血浆肾素活性降低有关（均值±标准差），对照组为16.71±2.76 ng/ml/小时，治疗组为9.60±3.84 ng/ml/小时。治疗组脐血中血浆醛固酮浓度较低，出生后第6天的样本也呈现类似趋势。提示分娩过程中内源性前列腺素生成增加可能是新生儿肾素-血管紧张素-醛固酮系统活性增强的原因之一。
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