Grey R H, Bird A C, Chisholm I H
Br J Ophthalmol. 1979 Feb;63(2):85-9. doi: 10.1136/bjo.63.2.85.
During a 1-year period 398 new patients were seen with disciform macular degeneration (530 eyes). The lesions were studied retrospectively, and those in which the neovascular tissue did not underlie the fovea, and therefore were treatable, were identified. The following conclusions were drawn: (1) Treatment is possible in most patients with good acuity and few with poor acuity. (2) Treatment is possible in a large proportion of patients with a short history and few with a long history of visual loss. (3) As many as 50% of all patients with senile disciform macular degeneration may be amenable to treatment if seen early enough in the course of their disease. (4) Over one-third of eyes with lesions that are untreated have a visual acuity of 6/60 or better 3 years after the onset of symptoms. (5) If a controlled trial proves that treatment is beneficial, these results emphasise the need for rapid referral and show that these patients will generate a large additional clinical load.
在1年期间，共诊治了398例盘状黄斑变性新患者（530只眼）。对这些病变进行了回顾性研究，确定了那些新生血管组织不在黄斑中心凹下方、因而可以治疗的病变。得出了以下结论：（1）大多数视力良好的患者可以接受治疗，而视力差的患者中少数也可以治疗。（2）在病程短的患者中，很大一部分可以接受治疗，而病程长的视力丧失患者中少数可以治疗。（3）如果在老年性盘状黄斑变性病程足够早期就进行诊治，所有患者中多达50%可能适合治疗。（4）三分之一以上未经治疗的病变眼在症状出现3年后视力为6/60或更好。（5）如果一项对照试验证明治疗有益，这些结果强调了快速转诊的必要性，并表明这些患者将带来大量额外的临床负担。
