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[环磷酰胺免疫抑制作用的药物遗传学方面]

[Pharmacogenetic aspects of the immunodepressive action of cyclophosphamide].

作者信息

Telegin L Iu

出版信息

Biull Eksp Biol Med. 1979 Mar;87(3):250-2.

PMID:427277
Abstract

The alkylating and immunodepressive activity of the serum of CBA, BALB/c and DBA/2 mice was studied after the cyclophosphamide administration. The interstrain differences between the indices under study were revealed; no direct correlation was shown between them. DBA/2 mice were found to be the most sensitive to the immunodepressive action of cyclophosphamide, and had the highest blood serum immunodepressive activity.

摘要

在给予环磷酰胺后，研究了CBA、BALB/c和DBA/2小鼠血清的烷基化和免疫抑制活性。揭示了所研究指标之间的品系间差异；它们之间未显示出直接相关性。发现DBA/2小鼠对环磷酰胺的免疫抑制作用最敏感，且血清免疫抑制活性最高。

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1
[Pharmacogenetic aspects of the immunodepressive action of cyclophosphamide].[环磷酰胺免疫抑制作用的药物遗传学方面]
Biull Eksp Biol Med. 1979 Mar;87(3):250-2.
2
[Immunodepressant action of cyclophosphamide in different strains of mice].
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