哺乳动物脂肪酸合成酶的调控。碳水化合物和胰岛素的作用。
Regulation of mammalian fatty-acid synthetase. The roles of carbohydrate and insulin.
作者信息
Volpe J J, Vagelos P R
出版信息
Proc Natl Acad Sci U S A. 1974 Mar;71(3):889-93. doi: 10.1073/pnas.71.3.889.
Abstract
The regulation of fatty-acid synthetase has been studied in liver, adipose tissue, and brain of diabetic and normal rats in relation to insulin administration and glucose or fructose feeding. The data indicate that: (1) insulin is not necessary for regulation of synthetase activity in liver but may be necessary in adipose tissue; (2) synthetase of liver can be regulated by carbohydrate, which can enter the glycolytic scheme in the absence of insulin (e.g., fructose), suggesting the possibility that regulation of synthetase may depend on the concentration of certain intermediates of the glycolytic pathway or beyond; (3) fructose feeding affects the synthetase by causing an increase in the rate of synthesis of fatty-acid synthetase; and (4) unlike fatty-acid synthetase of liver and adipose tissue, the enzyme of brain is unaffected by the diabetic state or by glucose or fructose feeding.
摘要
已经在糖尿病大鼠和正常大鼠的肝脏、脂肪组织及大脑中研究了脂肪酸合成酶的调节与胰岛素给药以及葡萄糖或果糖喂养的关系。数据表明：（1）胰岛素对于肝脏中合成酶活性的调节并非必需，但在脂肪组织中可能是必需的；（2）肝脏中的合成酶可由碳水化合物调节，碳水化合物在无胰岛素的情况下可进入糖酵解途径（例如果糖），这表明合成酶的调节可能取决于糖酵解途径或其以外某些中间产物的浓度；（3）果糖喂养通过使脂肪酸合成酶的合成速率增加来影响合成酶；（4）与肝脏和脂肪组织中的脂肪酸合成酶不同，大脑中的该酶不受糖尿病状态或葡萄糖或果糖喂养的影响。
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