淋病奈瑟菌因env基因突变导致低水平抗生素耐药性丧失。
Loss of low-level antibiotic resistance in Neisseria gonorrhoeae due to env mutations.
作者信息
Sarubbi F A, Sparling P F, Blackman E, Lewis E
出版信息
J Bacteriol. 1975 Nov;124(2):750-6. doi: 10.1128/jb.124.2.750-756.1975.
Abstract
Mutations (env) which resulted in increased sensitivity of gonococci to diverse compounds were studied by transformation. Strains carrying an env mutation were more sensitive than wild-type strains to several antibiotics, dyes, and detergents. The env mutations resulted in complete phenotypic suppression of low-level resistance to these same drugs determined by mutation at ery. Recombination was observed in transformation crosses between various env mutants. The env locus was not linked to the cluster of antibiotic resistance genes near str and spc.
摘要
通过转化研究了导致淋病奈瑟菌对多种化合物敏感性增加的突变（env）。携带env突变的菌株比野生型菌株对几种抗生素、染料和去污剂更敏感。env突变导致由ery位点突变所决定的对这些相同药物的低水平抗性的完全表型抑制。在各种env突变体之间的转化杂交中观察到了重组。env位点与靠近str和spc的抗生素抗性基因簇不连锁。
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