枯草芽孢杆菌中抗生素抗性标记的遗传图谱
Genetic mapping of antibiotic resistance in markers Bacillus subtilis.
作者信息
Goldthwaite C, Dubnau D, Smith I
出版信息
Proc Natl Acad Sci U S A. 1970 Jan;65(1):96-103. doi: 10.1073/pnas.65.1.96.
Abstract
Several antibiotic resistance markers in Bacillus subtilis have been mapped by three-factor transduction crosses using bacteriophage PBS1. These markers, which are thought to be located in genes coding for ribosomal proteins, are within a segment comprising about 5 per cent of the B. subtilis genetic map, close to the major group of rRNA cistrons. The order of genetic makers in this region was found to be cysA14 mic-1 dagger str-1 (ery-1, ole-2) spc-2 bry-2 lin-2. The positions of neo-2, nea-1, and kan-2 are uncertain, although they are located in this region to the right of cysA14.
摘要
利用噬菌体PBS1通过三因子转导杂交对枯草芽孢杆菌中的几种抗生素抗性标记进行了定位。这些标记被认为位于编码核糖体蛋白的基因中，它们位于枯草芽孢杆菌遗传图谱约5%的片段内，靠近rRNA顺反子的主要群体。发现该区域遗传标记的顺序为cysA14 mic-1匕首str-1（ery-1，ole-2）spc-2 bry-2 lin-2。neo-2、nea-1和kan-2的位置尚不确定，尽管它们位于cysA14右侧的该区域内。
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