通过高分辨率质量碎片分析法测定人乳腺肿瘤中的内源性类固醇浓度。
Endogenous steroid concentrations in human breast tumours determined by high-resolution mass fragmentography.
作者信息
Millington D, Jenner D A, Jones T, Griffiths K
出版信息
Biochem J. 1974 May;139(2):473-5. doi: 10.1042/bj1390473.
Abstract
A pilot study of the endogenous steroid concentrations in human breast tumours was performed. The technique of high-resolution molecular-ion monitoring during combined g.l.c.-mass spectrometry was used to determine oestrone, oestradiol-17beta and oestriol in concentrations above 1ng/g wet wt. of tissue, and dehydroepiandrosterone, testosterone, androsterone (3alpha-hydroxy-5alpha-androstan-17-one) and 3beta-hydroxy-5alpha-androstan-17-one in concentrations exceeding 5ng/g, in extracts of five primary breast tumours.
摘要
开展了一项关于人类乳腺肿瘤内源性类固醇浓度的初步研究。采用气相色谱 - 质谱联用期间的高分辨率分子离子监测技术，测定了5例原发性乳腺肿瘤提取物中浓度高于1ng/g组织湿重的雌酮、雌二醇 - 17β和雌三醇，以及浓度超过5ng/g的脱氢表雄酮、睾酮、雄酮（3α - 羟基 - 5α - 雄甾烷 - 17 - 酮）和3β - 羟基 - 5α - 雄甾烷 - 17 - 酮。
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