Engelsman E, Persijn J P, Korsten C B, Cleton F J
Br Med J. 1973 Jun 30;2(5869):750-2. doi: 10.1136/bmj.2.5869.750.
Oestrogen receptor determinations were done in metastatic breast cancer tissue of patients with advanced breast cancer. In 37 patients with progressive disease evaluation of the response to endocrine treatment was possible, following the criteria of the E.O.R.T.C. Co-operative Breast Cancer Group. In 20 patients with receptor-negative tumours two objective remissions were noted; in 17 patients with receptor-positive tumours 14 objective remissions were seen. There seems to be a striking correlation between the presence or absence of oestrogen receptor in tumour tissue and the clinical response to hormonal therapy.
对晚期乳腺癌患者的转移性乳腺癌组织进行了雌激素受体测定。按照欧洲癌症研究与治疗组织（E.O.R.T.C.）合作乳腺癌组的标准，对37例病情进展的患者进行了内分泌治疗反应评估。在20例受体阴性肿瘤患者中，观察到2例客观缓解；在17例受体阳性肿瘤患者中，观察到14例客观缓解。肿瘤组织中雌激素受体的有无与激素治疗的临床反应之间似乎存在显著相关性。
