半乳糖氨基聚糖与粗糙脉孢菌分生孢子的相互作用。
Interaction of galactosaminoglycan with Neurospora conidia.
作者信息
Glasgow J E, Reissig J L
出版信息
J Bacteriol. 1974 Nov;120(2):759-66. doi: 10.1128/jb.120.2.759-766.1974.
Abstract
The inactivation of Neurospora crassa conidia by galactosaminoglycan isolated from cultures of this organism was followed by measuring colony-forming ability and ability to take up radiolabeled metabolites. When kinetic data on the loss of transport function and on killing were analyzed by use of target theory, it appeared that few "hits" are required for inactivation. However, studies with radio-labeled galactosaminoglycan mucopolysaccharides showed that cells receiving a single lethal hit have approximately 10(5) galactosaminoglycan molecules bound to them.
摘要
通过测量集落形成能力和摄取放射性标记代谢物的能力，跟踪了从该生物体培养物中分离出的半乳糖胺聚糖对粗糙脉孢菌分生孢子的灭活作用。当利用靶理论分析运输功能丧失和杀伤的动力学数据时，发现灭活似乎只需要很少的“命中”次数。然而，对放射性标记的半乳糖胺聚糖粘多糖的研究表明，受到单次致死“命中”的细胞上大约结合有10⁵个半乳糖胺聚糖分子。
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