糖尿病中的细胞介导免疫。
Cell-mediated immunity in diabetes mellitus.
作者信息
Delespesse G, Duchateau J, Bastenie P A, Lauvaux J P, Collet H, Govaerts A
出版信息
Clin Exp Immunol. 1974 Dec;18(4):461-7.
Abstract
The quantified lymphocyte response to phytohaemagglutin (PHA) was investigated in fifty-six control subjects, classed according to age and sex, in twenty-nine insulin-dependent (IDD) and eight non-insulin-dependent diabetics. In nine cases one-way mixed lymphocyte cultures (MLC) were performed using mixed lymphocytes from IDD and paired controls. In the controls, a reduction of the response to PHA was observed with ageing; this was more marked in women than in men. The diabetics gave a greatly impaired response to PHA but only a slightly depressed response in MLC. These anomalies are not influenced by age but by the severity of the diabetes.
摘要
在56名按年龄和性别分类的对照受试者、29名胰岛素依赖型糖尿病患者（IDD）和8名非胰岛素依赖型糖尿病患者中，研究了对植物血凝素（PHA）的定量淋巴细胞反应。在9例病例中，使用来自IDD患者和配对对照的混合淋巴细胞进行单向混合淋巴细胞培养（MLC）。在对照中，观察到随着年龄增长对PHA的反应降低；在女性中比在男性中更明显。糖尿病患者对PHA的反应严重受损，但在MLC中反应仅略有降低。这些异常不受年龄影响，而是受糖尿病严重程度影响。
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