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1
Quantified deficiency of lymphocyte response to phytohaemagglutinin in immune deficiency diseases.免疫缺陷疾病中淋巴细胞对植物血凝素反应的定量缺陷。
Clin Exp Immunol. 1971 Oct;9(4):467-76.
2
Antigen-binding lymphocytes in children with immune deficiency.免疫缺陷患儿中的抗原结合淋巴细胞。
Clin Exp Immunol. 1972 Oct;12(2):161-9.
3
Membrane receptors and in vitro responsiveness of lymphocytes in human immunodeficiency.人类免疫缺陷中淋巴细胞的膜受体与体外反应性
J Immunol. 1974 Jan;112(1):376-86.
4
The establishment of a normal human population dose-response curve for lymphocytes cultured with PHA (phytohaemagglutinin).用植物血凝素（PHA）培养淋巴细胞的正常人群剂量反应曲线的建立。
Clin Exp Immunol. 1971 Mar;8(3):421-5.
5
Impaired lymphocyte transformation in ataxia-telangiectasia in part due to a plasma inhibitory factor.共济失调毛细血管扩张症中淋巴细胞转化受损部分归因于一种血浆抑制因子。
J Immunol. 1969 Dec;103(6):1212-22.
6
In vitro lymphocyte response in some immunity deficiency diseases and in intrauterine virus infections.某些免疫缺陷疾病及宫内病毒感染中的体外淋巴细胞反应。
Proc R Soc Med. 1970 Apr;63(4):351-4. doi: 10.1177/003591577006300410.
7
[Kinetic study of human lymphocytes transformation in culture by lectin from Pisum sativum (author's transl)].豌豆凝集素对人淋巴细胞体外转化作用的动力学研究（作者译）
Pathol Biol (Paris). 1976 Oct;24(8):517-24.
8
In vitro lymphocyte response of patients with immunologic deficiency diseases.免疫缺陷疾病患者的体外淋巴细胞反应。
N Engl J Med. 1970 Jun 11;282(24):1340-3. doi: 10.1056/NEJM197006112822404.
9
The primary immunodeficiency diseases: classification, pathogenesis and treatment.原发性免疫缺陷病：分类、发病机制与治疗
Turk J Pediatr. 1973 Oct;15(4):195-215.
10
Immunologic deficiency diseases.免疫缺陷疾病。
Bull Rheum Dis. 1971;22(9):686-91.

引用本文的文献

1
Mitogen responsiveness in viral hepatitis and chronic active hepatitis: the role of reversible suppressive influences.病毒性肝炎和慢性活动性肝炎中的有丝分裂原反应性：可逆性抑制影响的作用。
Gut. 1980 Sep;21(9):738-44. doi: 10.1136/gut.21.9.738.
2
A satisfactory quantitative test of lymphocyte response to phytohaemagglutinin for the definition of normal control values and recognition of immunological defects.一种用于确定正常对照值和识别免疫缺陷的对植物血凝素淋巴细胞反应的满意定量测试。
J Clin Pathol. 1972 Feb;25(2):163-8. doi: 10.1136/jcp.25.2.163.
3
Antigen-binding lymphocytes in children with immune deficiency.免疫缺陷患儿中的抗原结合淋巴细胞。
Clin Exp Immunol. 1972 Oct;12(2):161-9.
4
Immunological studies of Australia antigen carriers with and without liver diseases.对患有和未患有肝脏疾病的澳大利亚抗原携带者的免疫学研究。
Clin Exp Immunol. 1973 Sep;15(1):9-16.
5
Immunoglobulin-like surface molecules and theta antigen during the specific and non-specific stimulation of mouse spleen cells in vitro.体外对小鼠脾细胞进行特异性和非特异性刺激过程中的免疫球蛋白样表面分子和θ抗原
Clin Exp Immunol. 1972 Aug;11(4):523-34.
6
Lymphocyte subpopulations in the blood of newborn infants.新生儿血液中的淋巴细胞亚群。
Clin Exp Immunol. 1974 Dec;18(4):469-82.
7
Phytomitogen responses of peripheral blood lymphocytes in young and older subjects.年轻和年长受试者外周血淋巴细胞的植物促细胞分裂剂反应
Clin Exp Immunol. 1974 Aug;17(4):657-64.
8
A rapid micro-method for the phytohaemagglutinin-induced human lymphocyte transformation test.一种用于植物血凝素诱导的人淋巴细胞转化试验的快速微量方法。
Clin Exp Immunol. 1974 Sep;18(1):155-67.
9
Cell-mediated immunity in diabetes mellitus.糖尿病中的细胞介导免疫。
Clin Exp Immunol. 1974 Dec;18(4):461-7.
10
PHA-induced lymphocyte transformations in leucocyte cultures from malarious, malnourished and control Gambian children.来自冈比亚患疟疾、营养不良儿童及对照儿童的白细胞培养物中，PHA诱导的淋巴细胞转化
Clin Exp Immunol. 1974 Aug;17(4):647-56.

本文引用的文献

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Agammaglobulinemia.无丙种球蛋白血症
Pediatrics. 1952 Jun;9(6):722-8.
2
AGAMMAGLOBULINEMIA: THE FUNDAMENTAL DEFECT.无丙种球蛋白血症：根本缺陷
Science. 1964 Aug 7;145(3632):611-2. doi: 10.1126/science.145.3632.611.
3
The in vitro proliferation of lymphocytes from patients with hypogammaglobulinaemia.低丙种球蛋白血症患者淋巴细胞的体外增殖
Clin Exp Immunol. 1967 Sep;2(5):549-57.
4
Phytohemagglutinin response of recirculating and non-recirculating rat lymphocytes.
Exp Cell Res. 1969 Aug;56(2):219-23. doi: 10.1016/0014-4827(69)90005-6.
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Lymphocytes in congenital immunological deficiency diseases.先天性免疫缺陷疾病中的淋巴细胞。
Clin Exp Immunol. 1968 Oct;3(8):843-56.
6
A proposed classification of primary immunologic deficiencies.原发性免疫缺陷病的一种拟议分类。
Am J Med. 1968 Dec;45(6):817-25. doi: 10.1016/0002-9343(68)90180-0.
7
The establishment of a normal human population dose-response curve for lymphocytes cultured with PHA (phytohaemagglutinin).用植物血凝素（PHA）培养淋巴细胞的正常人群剂量反应曲线的建立。
Clin Exp Immunol. 1971 Mar;8(3):421-5.
8
Classification of the primary immune deficiencies: WHO recommendation.原发性免疫缺陷病的分类：世界卫生组织建议
N Engl J Med. 1970 Sep 17;283(12):656-7. doi: 10.1056/NEJM197009172831211.
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Pokeweed mitogen induced blastoid transformation in purified and non-purified leukocyte cultures.
Int Arch Allergy Appl Immunol. 1969;36(6):546-53. doi: 10.1159/000230775.
10
The response of leucocytes of agammaglobulinaemia subjects to phythohaemagglutinin and anti-immunoglobulin antiserum.无丙种球蛋白血症患者白细胞对植物血凝素和抗免疫球蛋白抗血清的反应。
Clin Exp Immunol. 1969 Feb;4(2):203-11.

免疫缺陷疾病中淋巴细胞对植物血凝素反应的定量缺陷。

Quantified deficiency of lymphocyte response to phytohaemagglutinin in immune deficiency diseases.

作者信息

Hosking C S, Fitzgerald M G, Simons M J

出版信息

Clin Exp Immunol. 1971 Oct;9(4):467-76.

PMID:5123224
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1713013/
Abstract

Using a quantitative assay of lymphocyte responsiveness to different concentrations of phytohaemagglutinin (PHA), it has been possible to demonstrate that the lymphocytes of children with ataxia telangiectasia do not respond normally. The response to PHA is nearer normal at higher concentrations of PHA. In the same system, it has been shown that although the lymphocytes of children with probable infantile sex-linked agammaglobulinaemia (Bruton's disease) may respond normally at higher concentrations of PHA, at lower concentrations their response is subnormal. The results reported indicate that if lymphocyte response to PHA is defective in an immune deficiency disease, then the response at lower concentrations of PHA provides the most sensitive discriminatory information.

摘要

通过对淋巴细胞对不同浓度植物血凝素（PHA）反应性的定量检测，已证实共济失调毛细血管扩张症患儿的淋巴细胞反应不正常。在较高浓度的PHA下，对PHA的反应更接近正常。在同一系统中，已表明尽管可能患有婴儿性连锁无丙种球蛋白血症（布鲁顿氏病）患儿的淋巴细胞在较高浓度的PHA下可能反应正常，但在较低浓度下其反应低于正常水平。所报道的结果表明，如果免疫缺陷疾病中淋巴细胞对PHA的反应存在缺陷，那么在较低浓度PHA下的反应能提供最敏感的鉴别信息。