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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Molteni P, De Simone V, Grosso E, Bianchi P A, Polli E

Biochem J. 1966 Jan;98(1):78-81. doi: 10.1042/bj0980078.

Mouse-fibroblast cultures in the stationary phase of growth show an increased rate of [(3)H]thymidine incorporation into DNA from 12 to 44hr. after infection with polyoma virus. 2. Intracellular virus progeny is first detected at about 24hr. after infection. 3. Calculations based on the [(3)H]thymidine-incorporation data and direct measurements of the DNA content of the cell cultures indicate that the amount of the excess of DNA synthesized by the infected cell cultures corresponds to about 10% of their total DNA. 4. The mitotic index of the cell cultures at 40hr. after infection was significantly higher than that of non-infected control cells. 5. Possible interpretations of the stimulation of DNA synthesis observed in polyoma-infected cell cultures are discussed.

处于生长静止期的小鼠成纤维细胞培养物在感染多瘤病毒后12至44小时内，[³H]胸腺嘧啶核苷掺入DNA的速率增加。2. 细胞内病毒后代最早在感染后约24小时被检测到。3. 根据[³H]胸腺嘧啶核苷掺入数据以及对细胞培养物DNA含量的直接测量进行的计算表明，受感染细胞培养物合成的过量DNA量约占其总DNA的10%。4. 感染后40小时细胞培养物的有丝分裂指数显著高于未感染的对照细胞。5. 讨论了在多瘤病毒感染的细胞培养物中观察到的DNA合成刺激的可能解释。

Molteni P, De Simone V, Grosso E, Bianchi P A, Polli E

Biochem J. 1966 Jan;98(1):78-81. doi: 10.1042/bj0980078.

Mouse-fibroblast cultures in the stationary phase of growth show an increased rate of [(3)H]thymidine incorporation into DNA from 12 to 44hr. after infection with polyoma virus. 2. Intracellular virus progeny is first detected at about 24hr. after infection. 3. Calculations based on the [(3)H]thymidine-incorporation data and direct measurements of the DNA content of the cell cultures indicate that the amount of the excess of DNA synthesized by the infected cell cultures corresponds to about 10% of their total DNA. 4. The mitotic index of the cell cultures at 40hr. after infection was significantly higher than that of non-infected control cells. 5. Possible interpretations of the stimulation of DNA synthesis observed in polyoma-infected cell cultures are discussed.

处于生长静止期的小鼠成纤维细胞培养物在感染多瘤病毒后12至44小时内，[³H]胸腺嘧啶核苷掺入DNA的速率增加。2. 细胞内病毒后代最早在感染后约24小时被检测到。3. 根据[³H]胸腺嘧啶核苷掺入数据以及对细胞培养物DNA含量的直接测量进行的计算表明，受感染细胞培养物合成的过量DNA量约占其总DNA的10%。4. 感染后40小时细胞培养物的有丝分裂指数显著高于未感染的对照细胞。5. 讨论了在多瘤病毒感染的细胞培养物中观察到的DNA合成刺激的可能解释。