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1
The effect of iron and transferrin on the killing of Escherichia coli in fresh serum.铁和转铁蛋白对新鲜血清中大肠杆菌杀伤作用的影响
Immunology. 1971 Apr;20(4):493-500.
2
Effect of iron on the bactericidal proteins from rabbit polymorphonuclear leukocytes.铁对兔多形核白细胞杀菌蛋白的影响。
Nature. 1970 Aug 22;227(5260):849-51. doi: 10.1038/227849a0.
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Immunology. 1970 Oct;19(4):521-38.
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The bacteriostatic effect of serum on Pasteurella septica and its abolition by iron compounds.血清对败血巴氏杆菌的抑菌作用及其被铁化合物消除的情况。
Immunology. 1971 Mar;20(3):391-406.
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引用本文的文献

1
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4
In vivo function of hemolysin in the nephropathogenicity of Escherichia coli.溶血素在大肠杆菌致肾病中的体内功能。
Infect Immun. 1983 Oct;42(1):245-9. doi: 10.1128/iai.42.1.245-249.1983.
5
On the transferrin concentration in serum of sows and growing pigs and in sow colostrum.关于母猪和生长猪血清中的转铁蛋白浓度以及母猪初乳中的转铁蛋白浓度。
Acta Vet Scand. 1974;15(1):120-34. doi: 10.1186/BF03547499.
6
Iron and infection.铁与感染
Eur J Clin Microbiol. 1985 Dec;4(6):537-9. doi: 10.1007/BF02013389.
7
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Infect Immun. 1988 Jan;56(1):275-7. doi: 10.1128/iai.56.1.275-277.1988.
8
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Eur J Clin Microbiol Infect Dis. 1991 Aug;10(8):613-7. doi: 10.1007/BF01975810.
9
Effect of gestational age and intrauterine nutrition on plasma transferrin and iron in the newborn.胎龄和宫内营养对新生儿血浆转铁蛋白及铁的影响。
Arch Dis Child. 1975 Oct;50(10):796-8. doi: 10.1136/adc.50.10.796.
10
Studies of transferrin polymorphism in Swedish cattle using agarose gel electrophoresis.利用琼脂糖凝胶电泳对瑞典奶牛转铁蛋白多态性的研究。
Acta Vet Scand. 1976;17(4):451-7. doi: 10.1186/BF03547900.

本文引用的文献

1
SIGNIFICANCE OF SERUM IRON FOR THE GROWTH, BIOLOGICAL CHARACTERISTICS, AND METABOLISM OF STAPHYLOCOCCUS AUREUS.血清铁对金黄色葡萄球菌生长、生物学特性及代谢的意义
Biochem Z. 1963;338:140-8.
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Macro and micro methods for the determination of serum iron and iron-binding capacity.
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Enhancement of growth of Pasteurella pestis and other bacteria in serum by the addition of iron.通过添加铁来增强鼠疫耶尔森菌和其他细菌在血清中的生长。
Br J Exp Pathol. 1961 Aug;42(4):363-8.
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Lysis of gram-negative organisms and the role of versene.革兰氏阴性菌的溶解及依地酸钠的作用
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The agglutination and sensitization of red cells by metallic cations: interactions between multivalent metals and the red-cell membrane.金属阳离子对红细胞的凝集和致敏作用：多价金属与红细胞膜之间的相互作用。
Br J Haematol. 1957 Jan;3(1):19-38. doi: 10.1111/j.1365-2141.1957.tb05768.x.
6
The virulence-enhancing effect of iron on nonpigmented mutants of virulent strains of Pasteurella pestis.铁对鼠疫耶尔森氏菌强毒株非色素突变体的毒力增强作用。
Br J Exp Pathol. 1956 Dec;37(6):577-83.
7
Studies on the heterogeneity of hemoglobin. IX. The use of Tris(hydroxymethyl)aminomethanehcl buffers in the anion-exchange chromatography of hemoglobins.血红蛋白异质性的研究。IX. 三（羟甲基）氨基甲烷盐酸盐缓冲液在血红蛋白阴离子交换色谱中的应用。
J Chromatogr. 1965 Jul;19(1):160-9. doi: 10.1016/s0021-9673(01)99434-8.
8
The abolition of the protective effect of Pasteurella septica antiserum by iron compounds.铁化合物对败血巴斯德氏菌抗血清保护作用的消除。
Immunology. 1968 Jun;14(6):889-98.
9
Ultraviolet difference spectrl studies of conalbumin complexes with transition metal ions.伴清蛋白与过渡金属离子复合物的紫外差光谱研究。
Biochemistry. 1969 Sep;8(9):3711-6. doi: 10.1021/bi00837a033.
10
A kinetic study of the bacteriolytic and bactericidal action of human serum.人体血清溶菌和杀菌作用的动力学研究。
Immunology. 1967 Jun;12(6):639-53.

铁和转铁蛋白对新鲜血清中大肠杆菌杀伤作用的影响

The effect of iron and transferrin on the killing of Escherichia coli in fresh serum.

作者信息

Fletcher J

出版信息

Immunology. 1971 Apr;20(4):493-500.

PMID:4994865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1455997/
Abstract

Iron in excess of the binding capacity of transferrin allows to grow in fresh serum. This appears to be due to two mechanisms. Firstly iron stimulates growth as it is an essential metabolite which is not available to in serum. Secondly, it interferes with bacterial killing, a process normally mediated by natural antibody and complement.

摘要

超过转铁蛋白结合能力的铁会在新鲜血清中促进其生长。这似乎是由于两种机制。首先，铁作为一种血清中无法获得的必需代谢物，会刺激生长。其次，它会干扰细菌杀灭过程，而这一过程通常由天然抗体和补体介导。