胆汁盐与钙吸收
Bile salts and calcium absorption.
作者信息
Webling D D, Holdsworth E S
出版信息
Biochem J. 1966 Sep;100(3):652-60. doi: 10.1042/bj1000652.
Abstract
- The study of the effect of bile salts on enhancing calcium absorption in the rachitic chick has been extended to bile salts not present in chick bile, e.g. glycine conjugates and bile alcohol sulphates. 2. Bile and bile salts cause an increase in calcium absorption from sparingly soluble calcium hydrogen phosphate when compared with a suspension of calcium hydrogen phosphate in saline. 3. If the bile ducts of normal rats are tied the absorption of calcium from calcium hydrogen phosphate decreases but can be restored by giving bile salts with the calcium salt. 4. Bile salts increase solubility in water of the sparingly soluble calcium salts, phytate and phosphate at pH values between 6 and 8. 5. Bile salts increase the solubility in lipid solvents of calcium in approximately the same proportion as they increase the absorption of calcium from the gut. 6. The physiological role of bile in calcium absorption and its mode of action are discussed.
摘要
- 关于胆盐对佝偻病雏鸡钙吸收增强作用的研究已扩展至鸡胆汁中不存在的胆盐，如甘氨酸共轭物和胆汁醇硫酸盐。2. 与磷酸氢钙在盐水中的悬浮液相比，胆汁和胆盐可使难溶性磷酸氢钙的钙吸收增加。3. 如果结扎正常大鼠的胆管，从磷酸氢钙中吸收的钙会减少，但通过给钙盐同时给予胆盐可使其恢复。4. 在pH值为6至8之间，胆盐可增加难溶性钙盐、植酸盐和磷酸盐在水中的溶解度。5. 胆盐增加钙在脂质溶剂中的溶解度的比例与它们增加肠道对钙的吸收的比例大致相同。6. 讨论了胆汁在钙吸收中的生理作用及其作用方式。
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本文引用的文献
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2
Influence of vitamin D on calcium absorption in the chick.维生素D对雏鸡钙吸收的影响。
Am J Physiol. 1962 Sep;203:497-505. doi: 10.1152/ajplegacy.1962.203.3.497.
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Am J Physiol. 1965 Feb;208:370-4. doi: 10.1152/ajplegacy.1965.208.2.370.
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Separation of bile acid conjugates by ion exchange chromatography.通过离子交换色谱法分离胆汁酸缀合物。
Can J Biochem Physiol. 1963 Jan;41:77-89.
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Biochem J. 1965 Aug;96(2):475-83. doi: 10.1042/bj0960475.
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