Liu S K, Maron B J, Tilley L P
J Am Vet Med Assoc. 1979 Apr 1;174(7):708-13.
Necropsy findings in 10 dogs with naturally occurring cardiac disease closely resembled hypertrophic cardiomyopathy in human beings and cats. Each dog had marked cardiac hypertrophy, and 8 dogs had disproportionate thickening of the ventricular septum with respect to the left ventricular free wall (compared with dogs with normal hearts or with cardiac hypertrophy due to acquired or congenital heart disease). Ratios of septum to free wall thickness in the 10 dogs ranged from 1.1 to 1.5, and 6 had ratios greater than or equal to 1.3. Marked cardiac muscle cell disorganization in the ventricular septum, characteristic of human patients with hypertrophic cardiomyopathy, was found in only 2 of the 10 dogs. Death occurred while the dogs were under anesthesia during the course of operative procedures (5 dogs) or unexpectedly in animals without previous manifestations of cardiac disease (3 dogs). Four dogs had clinical signs of congestive heart failure, including 2 with marked cardiac decompensation. Two of these 4 dogs with heart failure and 1 dog that died during unrelated surgery, but without prior signs of heart disease, had electrocardiographic evidence of complete heart block.
对10只患有自然发生的心脏病的犬进行尸检，其结果与人类和猫的肥厚型心肌病极为相似。每只犬均有明显的心脏肥大，其中8只犬的室间隔相对于左心室游离壁增厚不成比例（与心脏正常或因后天性或先天性心脏病导致心脏肥大的犬相比）。这10只犬的室间隔与游离壁厚度之比在1.1至1.5之间，其中6只犬的该比值大于或等于1.3。在10只犬中，只有2只犬的室间隔出现了明显的心肌细胞紊乱，这是人类肥厚型心肌病患者的特征。5只犬在手术过程中处于麻醉状态时死亡，3只此前无心脏病表现的犬意外死亡。4只犬有充血性心力衰竭的临床症状，其中2只出现明显的心功能不全。这4只心力衰竭的犬中有2只以及1只在 unrelated surgery（此处原文有误，推测可能是“无关手术”之意）期间死亡但此前无心脏病迹象的犬，有心电图显示完全性心脏传导阻滞。
