一种用于测量二氧化碳的连续记录技术及其在线粒体氧化和脱羧反应中的应用。
A continuous recording technique for the measurement of carbon dioxide, and its application to mitochondrial oxidation and decarboxylation reactions.
作者信息
Nicholls D G, Shepherd D, Garland P B
出版信息
Biochem J. 1967 Jun;103(3):677-91. doi: 10.1042/bj1030677.
Abstract
- A technique is described for continuously recording the concentration of carbon dioxide in mitochondrial suspensions. 2. The oxidation of palmitoylcarnitine by rat-liver mitochondria inhibits the oxidation of pyruvate and isocitrate, and stimulates the carboxylation of pyruvate. 3. These effects of palmitoylcarnitine oxidation are reversed by the uncoupling agent pentachlorophenol. 4. The effects of palmitoylcarnitine oxidation and pyruvate oxidation on the acylation of mitochondrial coenzyme A and reduction of nicotinamide nucleotides were measured. 5. Control mechanisms are discussed for the interactions between palmitoylcarnitine oxidation and the tricarboxylic acid cycle in rat-liver mitochondria.
摘要
- 本文描述了一种连续记录线粒体悬浮液中二氧化碳浓度的技术。2. 大鼠肝脏线粒体中棕榈酰肉碱的氧化会抑制丙酮酸和异柠檬酸的氧化，并刺激丙酮酸的羧化作用。3. 解偶联剂五氯苯酚可逆转棕榈酰肉碱氧化的这些作用。4. 测定了棕榈酰肉碱氧化和丙酮酸氧化对线粒体辅酶A酰化作用以及烟酰胺核苷酸还原作用的影响。5. 讨论了大鼠肝脏线粒体中棕榈酰肉碱氧化与三羧酸循环之间相互作用的调控机制。
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