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一种用于测量二氧化碳的连续记录技术及其在线粒体氧化和脱羧反应中的应用。

A continuous recording technique for the measurement of carbon dioxide, and its application to mitochondrial oxidation and decarboxylation reactions.

作者信息

Nicholls D G, Shepherd D, Garland P B

出版信息

Biochem J. 1967 Jun;103(3):677-91. doi: 10.1042/bj1030677.

DOI:10.1042/bj1030677
PMID:4292835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1270468/
Abstract
  1. A technique is described for continuously recording the concentration of carbon dioxide in mitochondrial suspensions. 2. The oxidation of palmitoylcarnitine by rat-liver mitochondria inhibits the oxidation of pyruvate and isocitrate, and stimulates the carboxylation of pyruvate. 3. These effects of palmitoylcarnitine oxidation are reversed by the uncoupling agent pentachlorophenol. 4. The effects of palmitoylcarnitine oxidation and pyruvate oxidation on the acylation of mitochondrial coenzyme A and reduction of nicotinamide nucleotides were measured. 5. Control mechanisms are discussed for the interactions between palmitoylcarnitine oxidation and the tricarboxylic acid cycle in rat-liver mitochondria.
摘要
  1. 本文描述了一种连续记录线粒体悬浮液中二氧化碳浓度的技术。2. 大鼠肝脏线粒体中棕榈酰肉碱的氧化会抑制丙酮酸和异柠檬酸的氧化，并刺激丙酮酸的羧化作用。3. 解偶联剂五氯苯酚可逆转棕榈酰肉碱氧化的这些作用。4. 测定了棕榈酰肉碱氧化和丙酮酸氧化对线粒体辅酶A酰化作用以及烟酰胺核苷酸还原作用的影响。5. 讨论了大鼠肝脏线粒体中棕榈酰肉碱氧化与三羧酸循环之间相互作用的调控机制。

相似文献

1
A continuous recording technique for the measurement of carbon dioxide, and its application to mitochondrial oxidation and decarboxylation reactions.一种用于测量二氧化碳的连续记录技术及其在线粒体氧化和脱羧反应中的应用。
Biochem J. 1967 Jun;103(3):677-91. doi: 10.1042/bj1030677.
2
Energy-dependent control of the tricarboxylic acid cycle by fatty acid oxidation in rat liver mitochondria.大鼠肝脏线粒体中脂肪酸氧化对三羧酸循环的能量依赖性调控
Adv Enzyme Regul. 1968;6:3-30. doi: 10.1016/0065-2571(68)90005-8.
3
The inhibition of pyruvate and Ls(+)-isocitrate oxidation by succinate oxidation in rat liver mitochondria.大鼠肝线粒体中琥珀酸氧化对丙酮酸和 L-(+)-异柠檬酸氧化的抑制作用。
Biochem J. 1969 Sep;114(3):589-96. doi: 10.1042/bj1140589.
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Feedback interactions in the control of citric acid cycle activity in rat heart mitochondria.大鼠心脏线粒体中柠檬酸循环活性调控的反馈相互作用
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Control of citrate synthesis in mitochondria.线粒体中柠檬酸合成的调控
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Effects of guanidine derivatives on mitochondrial function. I. Phenethylbiguanide inhibition of respiration in mitochondria from guinea pig and rat tissues.胍衍生物对线粒体功能的影响。I. 苯乙双胍对豚鼠和大鼠组织中线粒体呼吸的抑制作用。
J Clin Invest. 1968 Oct;47(10):2331-43. doi: 10.1172/JCI105918.
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The role of intermediates in mitochondrial fatty acid oxidation.中间体在线粒体脂肪酸氧化中的作用。
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Ketogenesis in isolated rat liver mitochondria. I. Relationships with the citric acid cycle and with the mitochondrial energy state.大鼠离体肝线粒体中的生酮作用。I. 与柠檬酸循环及线粒体能量状态的关系
Biochim Biophys Acta. 1972;283(1):1-15. doi: 10.1016/0005-2728(72)90092-8.
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Specific inhibition of mitochondrial fatty acid oxidation by 2-bromopalmitate and its coenzyme A and carnitine esters.2-溴软脂酸及其辅酶A和肉碱酯对线粒体脂肪酸氧化的特异性抑制作用。
Biochem J. 1972 Aug;129(1):55-65. doi: 10.1042/bj1290055.
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The formation of propionylcarnitine in isolated rat liver mitochondria.在分离的大鼠肝脏线粒体中丙酰肉碱的形成。
Biochim Biophys Acta. 1968 Dec 18;164(3):487-97.

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Biochem J. 1984 Feb 15;218(1):171-6. doi: 10.1042/bj2180171.
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Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Oxidative phosphorylation and mitochondrial oxidation of pyruvate, 3-hydroxybutyrate and tricarboxylic acid-cycle intermediates.降血糖化合物戊-4-烯酸及相关非降血糖脂肪酸的生化效应。丙酮酸、3-羟基丁酸和三羧酸循环中间体的氧化磷酸化及线粒体氧化。
Biochem J. 1968 Dec;110(3):499-509. doi: 10.1042/bj1100499.
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本文引用的文献

1
Carbonic anhydrase. Its preparation and properties.碳酸酐酶。其制备方法及性质。
J Physiol. 1933 Dec 5;80(2):113-42. doi: 10.1113/jphysiol.1933.sp003077.
2
Steady-state concentrations of coenzyme A, acetyl-coenzyme A and long-chain fatty acyl-coenzyme A in rat-liver mitochondria oxidizing palmitate.在氧化棕榈酸酯的大鼠肝脏线粒体中辅酶A、乙酰辅酶A和长链脂肪酰辅酶A的稳态浓度。
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Enzymatic synthesis of citric acid. II. Crystalline condensing enzyme.柠檬酸的酶促合成。II. 结晶缩合酶。
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DYNAMIC ASPECTS OF THE TRICARBOXYLIC ACID CYCLE IN ISOLATED MITOCHONDRIA.分离线粒体中三羧酸循环的动态方面
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[ON THE MECHANISM OF GLUCONEOGENESIS AND ITS REGULATION. I. QUANTITATIVE DETERMINATION OF PYRUVATE CARBOXYLASE IN RAW EXTRACTS OF RAT LIVER].[论糖异生作用的机制及其调节。I. 大鼠肝脏粗提物中丙酮酸羧化酶的定量测定]
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NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN.烟酰胺腺嘌呤二核苷酸特异性异柠檬酸脱氢酶。一种可能的调节蛋白。
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THE CROONIAN LECTURE, 1963. GLUCONEOGENESIS.1963年克罗尼安讲座。糖异生作用
Proc R Soc Lond B Biol Sci. 1964 Mar 17;159:545-64. doi: 10.1098/rspb.1964.0019.
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ACTIVATION AND INHIBITION OF DPN-LINKED ISOCITRATE DEHYDROGENASE OF HEART BY CERTAIN NUCLEOTIDES.某些核苷酸对心脏中与二磷酸硫胺素相关的异柠檬酸脱氢酶的激活与抑制作用
Biochemistry. 1963 Sep-Oct;2:1023-32. doi: 10.1021/bi00905a020.
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REGULATION OF PHOSPHOFRUCTOKINASE ACTIVITY BY CITRATE IN NORMAL AND DIABETIC MUSCLE.柠檬酸对正常及糖尿病肌肉中磷酸果糖激酶活性的调节
Biochem Biophys Res Commun. 1963 Aug 1;12:268-73. doi: 10.1016/0006-291x(63)90294-8.
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THE EFFECT OF ADENYLIC ACID ON YEAST NICOTINAMIDE ADENINE DINUCLEOTIDE ISOCITRATE DEHYDROGENASE, A POSSIBLE METABOLIC CONTROL MECHANISM.腺苷酸对酵母烟酰胺腺嘌呤二核苷酸异柠檬酸脱氢酶的影响，一种可能的代谢控制机制。
J Biol Chem. 1963 Aug;238:2875-81.