Comline R S, Fowden A L, Silver M
Q J Exp Physiol Cogn Med Sci. 1979 Oct;64(4):277-89. doi: 10.1113/expphysiol.1979.sp002482.
In acute experiments on pregnant sows under sodium pentobarbitone anaesthesia, acid base balance, oxygenation and plasma metabolite concentrations were well maintained in the dam and all fetuses which remained undisturbed in utero, irrespective of the duration of the experiment. Fetal liver glycogen concentrations were also unaffected by the time of removal of the fetus. By contrast, intravascular catheterization and withdrawal of blood led to fetal hyperglycaemia and depletion of hepatic glycogen although blood gas and pH values were not changed by these procedures. In the 1 1/2--2 h sampling period following catheterization the normal positive umbilical venous-arterial differences in plasma glucose and lactate generally became reversed. These changes were prevented by the administration of hexamethonium (10--15 mg . kg-1 i.v.) but the drug did not block the fall in hepatic glycogen in catheterized fetuses. Both adrenaline and noradrenaline, which were each infused intravenously at 2.7--3.9 or 0.6--0.9 microgram . kg-1 . min-1, resulted in fetal hyperglycaemia and lacticacidemia together with a fall in arterial blood pH; hepatic glycogen concentrations in these fetuses were also reduced. The apparent sensitivity of the glycogenolytic mechanism to surgical trauma and haemorrhage in the fetal piglet is discussed in relation to findings in other species.
在戊巴比妥钠麻醉下对怀孕母猪进行的急性实验中，无论实验持续时间多长，母体和所有未受干扰的子宫内胎儿的酸碱平衡、氧合及血浆代谢物浓度均维持良好。胎儿肝脏糖原浓度也不受胎儿取出时间的影响。相比之下，血管内插管和采血导致胎儿血糖升高和肝糖原消耗，尽管这些操作未改变血气和pH值。在插管后的1.5至2小时采样期内，血浆葡萄糖和乳酸正常的脐静脉 - 动脉阳性差值通常会逆转。六甲铵（10 - 15毫克·千克⁻¹静脉注射）可防止这些变化，但该药物不能阻止插管胎儿肝糖原的下降。肾上腺素和去甲肾上腺素分别以2.7 - 3.9或0.6 - 0.9微克·千克⁻¹·分钟⁻¹的速度静脉输注，均导致胎儿高血糖和乳酸血症，同时动脉血pH值下降；这些胎儿的肝糖原浓度也降低。结合其他物种的研究结果，讨论了仔猪糖原分解机制对外科创伤和出血的明显敏感性。
