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1
Enzymatic joining of DNA strands, II. An enzyme-adenylate intermediate in the dpn-dependent DNA ligase reaction.DNA链的酶促连接，II。依赖二磷酸吡啶核苷酸的DNA连接酶反应中的酶-腺苷酸中间体。
Proc Natl Acad Sci U S A. 1967 Nov;58(5):2004-11. doi: 10.1073/pnas.58.5.2004.
2
Joining of DNA strands by DNA ligase of E. coli.
Cold Spring Harb Symp Quant Biol. 1968;33:21-6. doi: 10.1101/sqb.1968.033.01.007.
3
On the mechanism of the polynucleotide joining reaction.论多核苷酸连接反应的机制。
Cold Spring Harb Symp Quant Biol. 1968;33:27-34. doi: 10.1101/sqb.1968.033.01.008.
4
Enzymatic joining of polynucleotides, V. A DNA-adenylate intermediate in the polynucleotide-joining reaction.多核苷酸的酶促连接，V. 多核苷酸连接反应中的DNA - 腺苷酸中间体
Proc Natl Acad Sci U S A. 1968 Sep;61(1):237-44. doi: 10.1073/pnas.61.1.237.
5
Ezymatic breakage and joining of deoxyribonucleic acid. VII. Properties of the enzyme-adenylate intermediate in the polynucleotide ligase reaction.脱氧核糖核酸的酶促断裂与连接。VII. 多核苷酸连接酶反应中酶 - 腺苷酸中间体的性质。
J Biol Chem. 1968 Sep 10;243(17):4556-63.
6
Enzymatic breakage and joining of deoxyribonucleic acid. IX. Synthesis and properties of the deoxyribonucleic acid adenylate in the phage T4 ligase reaction.脱氧核糖核酸的酶促断裂与连接。IX. 噬菌体T4连接酶反应中脱氧核糖核酸腺苷酸的合成与性质
J Biol Chem. 1971 Jul 25;246(14):4523-30.
7
Structure of the DNA ligase-adenylate intermediate: lysine (epsilon-amino)-linked adenosine monophosphoramidate.DNA连接酶-腺苷酸中间体的结构：赖氨酸（ε-氨基）连接的单磷酸腺苷酰胺
Proc Natl Acad Sci U S A. 1971 Oct;68(10):2559-63. doi: 10.1073/pnas.68.10.2559.
8
Enzymatic breakage and joining of deoxyribonucleic acid. IV. DNA synthesis in E. coli infected with ligase-negative mutants of phage T4.脱氧核糖核酸的酶促断裂与连接。IV. 感染噬菌体T4连接酶阴性突变体的大肠杆菌中的DNA合成。
Proc Natl Acad Sci U S A. 1968 Dec;61(4):1328-35. doi: 10.1073/pnas.61.4.1328.
9
Enzymatic breadage and joining of deoxyribonucleic acid. 3. An enzyme-adenylate intermediate in the polynucleotide ligase reaction.脱氧核糖核酸的酶促断裂与连接。3. 多核苷酸连接酶反应中的酶 - 腺苷酸中间体。
J Biol Chem. 1967 Sep 25;242(18):4270-2.
10
Studies on the joining of DNA by polynucleotide ligase of phage T4.噬菌体T4多核苷酸连接酶对DNA连接作用的研究。
Cold Spring Harb Symp Quant Biol. 1968;33:151-64. doi: 10.1101/sqb.1968.033.01.019.

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Modulation of protein activity by small RNA base pairing internal to coding sequences.通过编码序列内部的小RNA碱基配对对蛋白质活性进行调控。
Mol Cell. 2025 May 1;85(9):1824-1837.e7. doi: 10.1016/j.molcel.2025.03.014. Epub 2025 Apr 7.
2
Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD-dependent polynucleotide ligases.ATP 依赖性和 NAD 依赖性多核苷酸连接酶赖氨酸腺苷酸化的双金属与单金属机制
Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2592-2597. doi: 10.1073/pnas.1619220114. Epub 2017 Feb 21.
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Kinetic mechanism and fidelity of nick sealing by Escherichia coli NAD+-dependent DNA ligase (LigA).大肠杆菌NAD+依赖型DNA连接酶（LigA）切口封闭的动力学机制及保真度
Nucleic Acids Res. 2016 Mar 18;44(5):2298-309. doi: 10.1093/nar/gkw049. Epub 2016 Feb 8.
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Synthetic DNA: the next generation of big data storage.合成 DNA：下一代大数据存储。
Bioengineered. 2013 May-Jun;4(3):123-5. doi: 10.4161/bioe.24296. Epub 2013 Mar 20.
5
Structure-guided Mutational Analysis of the Nucleotidyltransferase Domain of Escherichia coli DNA Ligase (LigA).大肠杆菌DNA连接酶（LigA）核苷酸转移酶结构域的结构导向突变分析
J Biol Chem. 2009 Mar 27;284(13):8486-94. doi: 10.1074/jbc.M808476200. Epub 2009 Jan 15.
6
Structure-guided mutational analysis of the OB, HhH, and BRCT domains of Escherichia coli DNA ligase.大肠杆菌DNA连接酶的OB、HhH和BRCT结构域的结构导向突变分析
J Biol Chem. 2008 Aug 22;283(34):23343-52. doi: 10.1074/jbc.M802945200. Epub 2008 May 30.
7
Analysis of the DNA joining repertoire of Chlorella virus DNA ligase and a new crystal structure of the ligase-adenylate intermediate.小球藻病毒DNA连接酶的DNA连接谱分析及连接酶-腺苷酸中间体的新晶体结构
Nucleic Acids Res. 2003 Sep 1;31(17):5090-100. doi: 10.1093/nar/gkg665.
8
Helicobacter pylori extracts exhibit nicotinamide adenine dinucleotide-derived adenylation but not mono(adenosine 5'-diphosphate-ribosyl)ation of DNA ligase.幽门螺杆菌提取物表现出烟酰胺腺嘌呤二核苷酸衍生的腺苷化作用，但对DNA连接酶没有单（腺苷5'-二磷酸核糖基）化作用。
Jpn J Cancer Res. 1997 Oct;88(10):921-4. doi: 10.1111/j.1349-7006.1997.tb00308.x.
9
Capacity for postreplication repair correlated with transducibility in Rec- mutants of Bacillus subtilis.枯草芽孢杆菌Rec-突变体中的复制后修复能力与转导性相关。
J Bacteriol. 1980 Nov;144(2):608-15. doi: 10.1128/jb.144.2.608-615.1980.
10
Alteration of gene conversion patterns in Sordaria fimicola by supplementation with DNA bases.通过补充DNA碱基改变粪生粪壳菌中的基因转换模式。
Proc Natl Acad Sci U S A. 1970 Aug;66(4):1290-7. doi: 10.1073/pnas.66.4.1290.

本文引用的文献

1
COHESION OF DNA MOLECULES ISOLATED FROM PHAGE LAMBDA.从噬菌体λ中分离出的DNA分子的凝聚作用
Proc Natl Acad Sci U S A. 1963 May;49(5):748-55. doi: 10.1073/pnas.49.5.748.
2
THE FATE OF NICOTINAMIDE IN THE MOUSE; TISSUE METABOLITES.小鼠体内烟酰胺的命运；组织代谢物
Biochim Biophys Acta. 1965 May 4;100:351-65. doi: 10.1016/0304-4165(65)90004-8.
3
SEDIMENTATION STUDIES OF THE SIZE AND SHAPE OF DNA.DNA大小与形状的沉降研究
J Mol Biol. 1965 Feb;11:373-90. doi: 10.1016/s0022-2836(65)80064-x.
4
Biosynthesis of diphosphopyridine nucleotide. I. Identification of intermediates.二磷酸吡啶核苷酸的生物合成。I. 中间产物的鉴定。
J Biol Chem. 1958 Aug;233(2):488-92.
5
Linkage of polynucleotides through phosphodiester bonds by an enzyme from Escherichia coli.来自大肠杆菌的一种酶通过磷酸二酯键连接多核苷酸。
Proc Natl Acad Sci U S A. 1967 May;57(5):1426-33. doi: 10.1073/pnas.57.5.1426.
6
Enzymatic breakage and joining of deoxyribonucleic acid, I. Repair of single-strand breaks in DNA by an enzyme system from Escherichia coli infected with T4 bacteriophage.脱氧核糖核酸的酶促断裂与连接，I. 用感染T4噬菌体的大肠杆菌的酶系统修复DNA中的单链断裂
Proc Natl Acad Sci U S A. 1967 Apr;57(4):1021-8. doi: 10.1073/pnas.57.4.1021.
7
Phosphorylation of nucleic acid by an enzyme from T4 bacteriophage-infected Escherichia coli.来自T4噬菌体感染的大肠杆菌的一种酶对核酸的磷酸化作用。
Proc Natl Acad Sci U S A. 1965 Jul;54(1):158-65. doi: 10.1073/pnas.54.1.158.
8
Enzymatic breakage and joining of deoxyribonucleic acid. II. The structural gene for polynucleotide ligase in bacteriophage T4.脱氧核糖核酸的酶促断裂与连接。II. 噬菌体T4中多核苷酸连接酶的结构基因
Proc Natl Acad Sci U S A. 1967 Aug;58(2):665-72. doi: 10.1073/pnas.58.2.665.
9
Formation of covalent circles of lambda DNA by E. coli extracts.大肠杆菌提取物形成λ噬菌体DNA共价环。
Proc Natl Acad Sci U S A. 1967 Jan;57(1):148-55. doi: 10.1073/pnas.57.1.148.
10
Enzymatic joining of DNA strands: a novel reaction of diphosphopyridine nucleotide.DNA链的酶促连接：二磷酸吡啶核苷酸的一种新反应。
Proc Natl Acad Sci U S A. 1967 Jun;57(6):1841-8. doi: 10.1073/pnas.57.6.1841.

Enzymatic joining of DNA strands, II. An enzyme-adenylate intermediate in the dpn-dependent DNA ligase reaction.

作者信息

Little J W, Zimmerman S B, Oshinsky C K, Gellert M

出版信息

Proc Natl Acad Sci U S A. 1967 Nov;58(5):2004-11. doi: 10.1073/pnas.58.5.2004.

DOI:10.1073/pnas.58.5.2004
PMID:4295585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC223897/
Abstract
摘要