网状脊髓束对中间神经元的抑制作用
Reticulospinal inhibition of interneurones.
作者信息
Engberg I, Lundberg A, Ryall R W
出版信息
J Physiol. 1968 Jan;194(1):225-36. doi: 10.1113/jphysiol.1968.sp008403.
Abstract
- The effect of electrical stimulation of the brain stem on interneurones in the dorsal horn and intermediary region has been investigated in decerebrate cats after partial transection of the spinal cord.2. Stimuli that effectively depress reflex transmission without giving a primary afferent depolarization inhibit the discharge evoked from the flexor reflex afferents in interneurones.3. Brain stem stimulation did not give post-synaptic potentials in the great majority of interneurones but effectively depressed the excitatory post-synaptic potentials (EPSPs) and inhibitory post-synaptic potentials (IPSPs) evoked from the flexor reflex afferents in these interneurones.4. IPSPs were, however, evoked in five of seventy-eight intracellularly recorded interneurones. These five interneurones were monosynaptically activated from primary afferents.5. It is tentatively postulated that a dorsal reticulospinal system inhibits reflex transmission by giving post-synaptic inhibition in first order interneurones. The results are also discussed in relation to effects on interneurones from other descending pathways.
摘要
在脊髓部分横断的去大脑猫中，研究了脑干电刺激对背角和中间区域中间神经元的影响。
能有效抑制反射传递而不产生初级传入去极化的刺激，可抑制中间神经元中由屈肌反射传入纤维诱发的放电。
脑干刺激在绝大多数中间神经元中未产生突触后电位，但能有效抑制这些中间神经元中由屈肌反射传入纤维诱发的兴奋性突触后电位（EPSP）和抑制性突触后电位（IPSP）。
然而，在78个经细胞内记录的中间神经元中有5个诱发出了IPSP。这5个中间神经元由初级传入纤维单突触激活。
初步推测，背侧网状脊髓系统通过在一级中间神经元中产生突触后抑制来抑制反射传递。还结合其他下行通路对中间神经元的影响讨论了这些结果。
相似文献
1
Reticulospinal inhibition of interneurones.网状脊髓束对中间神经元的抑制作用
J Physiol. 1968 Jan;194(1):225-36. doi: 10.1113/jphysiol.1968.sp008403.
2
Reticulospinal inhibition of transmission in reflex pathways.网状脊髓束对反射通路中神经冲动传递的抑制作用。
J Physiol. 1968 Jan;194(1):201-23. doi: 10.1113/jphysiol.1968.sp008402.
3
Presynaptic control of transmission along the pathway mediating disynaptic reciprocal inhibition in the cat.猫中沿介导双突触交互抑制的通路进行传递的突触前控制。
J Physiol. 2000 Aug 1;526 Pt 3(Pt 3):623-37. doi: 10.1111/j.1469-7793.2000.t01-1-00623.x.
4
Reflex pathways from group II muscle afferents. 2. Functional characteristics of reflex pathways to alpha-motoneurones.来自II类肌传入纤维的反射通路。2. 至α运动神经元的反射通路的功能特征。
Exp Brain Res. 1987;65(2):282-93. doi: 10.1007/BF00236300.
5
Indications for coupling between feline spinocervical tract neurones and midlumbar interneurones.猫脊髓颈段束神经元与腰髓中间神经元之间耦合的指征。
Exp Brain Res. 1998 Mar;119(1):39-46. doi: 10.1007/s002210050317.
6
Medullary reticulospinal tract mediating the generalized motor inhibition in cats: parallel inhibitory mechanisms acting on motoneurons and on interneuronal transmission in reflex pathways.延髓网状脊髓束介导猫的全身性运动抑制：作用于运动神经元和反射通路中神经元间传递的平行抑制机制。
Neuroscience. 2001;103(2):511-27. doi: 10.1016/s0306-4522(00)00586-8.
7
Evidence that mid-lumbar neurones in reflex pathways from group II afferents are involved in locomotion in the cat.来自II类传入纤维的反射通路中的腰中部神经元参与猫运动的证据。
J Physiol. 1988 Sep;403:57-71. doi: 10.1113/jphysiol.1988.sp017238.
8
Both dorsal horn and lamina VIII interneurones contribute to crossed reflexes from feline group II muscle afferents.背角和第VIII层中间神经元都参与猫II类肌传入纤维的交叉反射。
J Physiol. 2003 Nov 1;552(Pt 3):961-74. doi: 10.1113/jphysiol.2003.048009. Epub 2003 Sep 8.
9
Integration in descending motor pathways controlling the forelimb in the cat. 12. Interneurones which may mediate descending feed-forward inhibition and feed-back inhibition from the forelimb to C3-C4 propriospinal neurones.猫前肢下行运动通路中的整合。12. 可能介导从前肢到C3 - C4脊髓固有神经元的下行前馈抑制和反馈抑制的中间神经元。
Exp Brain Res. 1984;56(2):308-22. doi: 10.1007/BF00236286.
10
Relative contribution of Ia inhibitory interneurones to inhibition of feline contralateral motoneurones evoked via commissural interneurones.Ia抑制性中间神经元对经连合中间神经元诱发的猫对侧运动神经元抑制的相对贡献。
J Physiol. 2005 Oct 15;568(Pt 2):617-28. doi: 10.1113/jphysiol.2005.088351. Epub 2005 Aug 11.
引用本文的文献
1
Identifying spinal tracts transmitting distant effects of trans-spinal magnetic stimulation.识别经脊髓磁刺激传递远距离效应的脊髓束。
J Neurophysiol. 2023 Oct 1;130(4):883-894. doi: 10.1152/jn.00202.2023. Epub 2023 Aug 30.
2
Simultaneous Assessment of Homonymous and Heteronymous Monosynaptic Reflex Excitability in the Adult Rat.成年大鼠同侧和异侧单突触反射兴奋性的同步评估。
eNeuro. 2018 Oct 16;5(5). doi: 10.1523/ENEURO.0227-18.2018. eCollection 2018 Sep-Oct.
3
StartReact during gait initiation reveals differential control of muscle activation and inhibition in patients with corticospinal degeneration.起始运动期的起始反应揭示皮质脊髓变性患者肌肉激活和抑制的控制存在差异。
J Neurol. 2018 Nov;265(11):2531-2539. doi: 10.1007/s00415-018-9027-0. Epub 2018 Aug 28.
4
Pathophysiology of spasticity: implications for neurorehabilitation.痉挛的病理生理学：对神经康复的启示。
Biomed Res Int. 2014;2014:354906. doi: 10.1155/2014/354906. Epub 2014 Oct 30.
5
Effects of reversible spinalization on individual spinal neurons.可逆性脊柱切断术对单个脊髓神经元的影响。
J Neurosci. 2013 Nov 27;33(48):18987-98. doi: 10.1523/JNEUROSCI.2394-13.2013.
6
Organisation of sensitisation of hind limb withdrawal reflexes from acute noxious stimuli in the rabbit.家兔急性伤害性刺激后肢退缩反射的敏化组织
J Physiol. 2003 Jan 1;546(Pt 1):251-65. doi: 10.1113/jphysiol.2002.025023.
7
Bulbospinal control of spinal cord pathways generating locomotor extensor activities in the cat.猫中产生运动性伸肌活动的脊髓通路的延髓脊髓控制
J Physiol. 2000 May 15;525 Pt 1(Pt 1):225-40. doi: 10.1111/j.1469-7793.2000.t01-1-00225.x.
8
Integration in descending motor pathways controlling the forelimb in the cat. 7. Effects from the reticular formation on C3-C4 propriospinal neurones.猫前肢下行运动通路中的整合。7. 网状结构对C3 - C4脊髓固有神经元的影响。
Exp Brain Res. 1981;42(3-4):269-81. doi: 10.1007/BF00237494.
9
The antinociceptive action of etorphine in the dorsal horn is due to a direct spinal action and not to activation of descending inhibition.埃托啡在脊髓背角的抗伤害感受作用是由于其直接的脊髓作用，而非下行抑制的激活。
Br J Pharmacol. 1983 Feb;78(2):307-19. doi: 10.1111/j.1476-5381.1983.tb09396.x.
10
Neuropeptides and monoaminergic neurotransmitters: their relation to pain.神经肽与单胺能神经递质：它们与疼痛的关系。
J R Soc Med. 1980 Jul;73(7):482-91. doi: 10.1177/014107688007300704.
本文引用的文献
1
Nature and significance of the reflex connections established by large afferent fibers of muscular origin.肌肉来源的大传入纤维建立的反射联系的性质和意义。
Am J Physiol. 1952 Jun;169(3):609-21. doi: 10.1152/ajplegacy.1952.169.3.609.
2
SUPRASPINAL CONTROL OF TRANSMISSION IN REFLEX PATHS TO MOTONEURONES AND PRIMARY AFFERENTS.脊髓以上对反射通路中运动神经元和初级传入纤维传导的控制。
Prog Brain Res. 1964;12:197-221. doi: 10.1016/s0079-6123(08)60624-x.
3
DECEREBRATE CONTROL OF REFLEXES TO PRIMARY AFFERENTS.去大脑对初级传入反射的控制
Acta Physiol Scand. 1963 Dec;59:424-37. doi: 10.1111/j.1748-1716.1963.tb02758.x.
4
Pyramidal effects on lumbo-sacral interneurones activated by somatic afferents.躯体传入神经激活对腰骶中间神经元的锥体束效应。
Acta Physiol Scand. 1962 Nov-Dec;56:220-9. doi: 10.1111/j.1748-1716.1962.tb02497.x.
5
Effects from the pyramidal tract on spinal reflex arcs.锥体束对脊髓反射弧的影响。
Acta Physiol Scand. 1962 Nov-Dec;56:201-19. doi: 10.1111/j.1748-1716.1962.tb02498.x.
6
Supraspinal control of interneurones mediating spinal reflexes.介导脊髓反射的中间神经元的脊髓上控制
J Physiol. 1959 Oct;147(3):565-84. doi: 10.1113/jphysiol.1959.sp006262.
7
Synaptic actions on motoneurones caused by impulses in Golgi tendon organ afferents.高尔基腱器官传入纤维冲动对运动神经元的突触作用。
J Physiol. 1957 Sep 30;138(2):227-52. doi: 10.1113/jphysiol.1957.sp005849.
8
Convergence of excitatory and inhibitory action on interneurones in the lumbosacral cord.腰骶髓中对中间神经元的兴奋性和抑制性作用的汇聚
Exp Brain Res. 1966;1(4):338-58. doi: 10.1007/BF00237706.
9
Effects evoked from the rubrospinal tract in cats.猫红核脊髓束所引发的效应。
Experientia. 1965 Sep 15;21(9):525-6. doi: 10.1007/BF02138973.
10
Reticulospinal inhibition of transmission in reflex pathways.网状脊髓束对反射通路中神经冲动传递的抑制作用。
J Physiol. 1968 Jan;194(1):201-23. doi: 10.1113/jphysiol.1968.sp008402.
Zotero 插件