网状脊髓束对中间神经元的抑制作用

Reticulospinal inhibition of interneurones.

作者信息

Engberg I, Lundberg A, Ryall R W

出版信息

J Physiol. 1968 Jan;194(1):225-36. doi: 10.1113/jphysiol.1968.sp008403.

DOI:10.1113/jphysiol.1968.sp008403

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1365683/

Abstract

The effect of electrical stimulation of the brain stem on interneurones in the dorsal horn and intermediary region has been investigated in decerebrate cats after partial transection of the spinal cord.2. Stimuli that effectively depress reflex transmission without giving a primary afferent depolarization inhibit the discharge evoked from the flexor reflex afferents in interneurones.3. Brain stem stimulation did not give post-synaptic potentials in the great majority of interneurones but effectively depressed the excitatory post-synaptic potentials (EPSPs) and inhibitory post-synaptic potentials (IPSPs) evoked from the flexor reflex afferents in these interneurones.4. IPSPs were, however, evoked in five of seventy-eight intracellularly recorded interneurones. These five interneurones were monosynaptically activated from primary afferents.5. It is tentatively postulated that a dorsal reticulospinal system inhibits reflex transmission by giving post-synaptic inhibition in first order interneurones. The results are also discussed in relation to effects on interneurones from other descending pathways.

摘要

在脊髓部分横断的去大脑猫中，研究了脑干电刺激对背角和中间区域中间神经元的影响。
能有效抑制反射传递而不产生初级传入去极化的刺激，可抑制中间神经元中由屈肌反射传入纤维诱发的放电。
脑干刺激在绝大多数中间神经元中未产生突触后电位，但能有效抑制这些中间神经元中由屈肌反射传入纤维诱发的兴奋性突触后电位（EPSP）和抑制性突触后电位（IPSP）。
然而，在78个经细胞内记录的中间神经元中有5个诱发出了IPSP。这5个中间神经元由初级传入纤维单突触激活。
初步推测，背侧网状脊髓系统通过在一级中间神经元中产生突触后抑制来抑制反射传递。还结合其他下行通路对中间神经元的影响讨论了这些结果。