肝细胞核中烟酰胺腺嘌呤二核苷酸焦磷酸化酶的活性。肝部分切除术、肝毒素及饮食变化的影响。
Activity of nicotinamide-adenine dinucleotide pyrophosphorylase in liver nuclei. Effects of partial hepatectomy, hepatotoxins and dietary changes.
作者信息
Stirpe F, Della Corte E
出版信息
Biochem J. 1968 Jun;108(1):89-93. doi: 10.1042/bj1080089.
Abstract
- The activity of NAD pyrophosphorylase is lower in nuclei isolated from regenerating rat liver than in normal nuclei, and this is due to leakage of the enzyme from the nuclei during the isolation. 2. The NAD pyrophosphorylase activity is lower in liver nuclei from newborn rats, and from rats on a protein-free diet, but no leakage occurs in these cases. 3. Poisoning with alpha-amanitin brings about a transient enhancement of NAD pyrophosphorylase activity in mouse liver nuclei. 4. No changes of enzyme activity were observed after 72hr. starvation, administration of actinomycin D or infection with MHV3 virus.
摘要
- 从再生大鼠肝脏分离出的细胞核中，NAD焦磷酸化酶的活性低于正常细胞核，这是由于在分离过程中该酶从细胞核中泄漏所致。2. 新生大鼠以及食用无蛋白饮食的大鼠的肝细胞核中，NAD焦磷酸化酶的活性较低，但在这些情况下不会发生泄漏。3. 用α-鹅膏蕈碱中毒会使小鼠肝细胞核中NAD焦磷酸化酶的活性短暂增强。4. 在饥饿72小时、给予放线菌素D或感染MHV3病毒后，未观察到酶活性的变化。
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