• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

小鼠Ia同种异体抗原的结构研究。V. I-E/Cβ多肽结构基因在I-A亚区内编码的证据。

Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion.

作者信息

Cook R G, Vitetta E S, Uhr J W, Capra J D

出版信息

J Exp Med. 1979 Apr 1;149(4):981-6. doi: 10.1084/jem.149.4.981.

DOI:10.1084/jem.149.4.981
PMID:429967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2184847/
Abstract

The E/C alpha- and beta-subunits of intra-I-region recombinants were analyzed for primary structural variation by comparative tryptic peptide mapping. The E/C alpha-polypeptides from B10.A, B10.A (3R) and B10.A (5R) showed complete coincident elution of peptides; the E/C beta-chains from B10.A and 3R (or 5R) were approximately 40% different. This suggests that the structural gene for the E/C beta-polypeptide is within the I-A subregion.

摘要

通过比较胰蛋白酶肽图谱分析I区内重组体的E/Cα和β亚基的一级结构变异。来自B10.A、B10.A（3R）和B10.A（5R）的E/Cα多肽显示出肽的完全一致洗脱；来自B10.A和3R（或5R）的E/Cβ链大约有40%的差异。这表明E/Cβ多肽的结构基因位于I-A亚区内。

相似文献

1
Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion.小鼠Ia同种异体抗原的结构研究。V. I-E/Cβ多肽结构基因在I-A亚区内编码的证据。
J Exp Med. 1979 Apr 1;149(4):981-6. doi: 10.1084/jem.149.4.981.
2
Structural studies on the murine Ia alloantigens. VI. Evidence that both subunits of the I-A alloantigen are encoded by the I-A subregion.小鼠Ia同种异体抗原的结构研究。VI. I-A同种异体抗原的两个亚基均由I-A亚区编码的证据。
J Immunol. 1979 Dec;123(6):2799-803.
3
Structural studies on the murine Ia alloantigens. IV. NH2-terminal sequence analysis of allelic products of the I-A and I-E/C subregions.小鼠Ia同种异体抗原的结构研究。IV. I-A和I-E/C亚区等位基因产物的NH2末端序列分析。
J Immunol. 1979 Jun;122(6):2232-7.
4
Structural studies on the murine Ia alloantigens. VII. Further evidence for two-gene control of the E/C alloantigens.小鼠Ia同种异体抗原的结构研究。VII. E/C同种异体抗原双基因控制的进一步证据。
J Immunol. 1980 Apr;124(4):1594-8.
5
Role of I-J-subregion gene products in the regulation of macrophage-T-Lymphocyte interaction.I-J亚区基因产物在巨噬细胞与T淋巴细胞相互作用调节中的作用。
Transplant Proc. 1979 Mar;11(1):727-31.
6
Definitive mapping of the immune response gene(s) for (T,G)-A--L to the I-A subregion.针对（T，G）-A--L免疫反应基因到I-A亚区的精确定位。
J Immunol. 1980 Jun;124(6):2909-11.
7
Structural studies on the murine IA alloantigens. II. Molecular weight characterization of the products of the I-A and I-E/C subregions.小鼠IA同种异体抗原的结构研究。II. I-A和I-E/C亚区产物的分子量特征
J Immunol. 1978 Dec;121(6):2205-12.
8
Peptide map analyses of murine Ia antigens of the I-E subregion using HPLC.使用高效液相色谱法对I-E亚区小鼠Ia抗原进行肽图谱分析。
Nature. 1979 Feb 22;277(5698):663-5. doi: 10.1038/277663a0.
9
Structural polymorphism of I-E subregion antigens determined by a gene in the H-2K to I-B genetic interval.I-E 亚区抗原结构多态性由 H-2K 到 I-B 遗传间隔内的一个基因决定。
Nature. 1979 May 31;279(5712):437-9. doi: 10.1038/279437a0.
10
Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in Ae:E alpha complex expression causes a corresponding defect in antigen-presenting cell function.免疫反应基因功能与Ia抗原的表达相关。II. Ae:Eα复合体表达的定量缺陷导致抗原呈递细胞功能出现相应缺陷。
J Exp Med. 1982 Feb 1;155(2):508-23. doi: 10.1084/jem.155.2.508.

引用本文的文献

1
Biochemical characterization of murine Ia antigens with xenoantisera. I. Identification of a second la molecule (I-E?) in H-2s haplotype.用异种抗血清对鼠 Ia 抗原的生化特性分析。I. 在 H-2s 单倍型中鉴定出第二种 Ia 分子（I-E?）。
Immunogenetics. 1980;10(4):311-8. doi: 10.1007/BF01561581.
2
Identification of two Ia-like alloantigens on rabbit B lymphocytes.鉴定兔 B 淋巴细胞上的两种 Ia 样同种异体抗原。
Immunogenetics. 1980;10(5):443-53. doi: 10.1007/BF01572580.
3
Serological and biochemical identification of hybrid Ia antigens.杂交Ia抗原的血清学和生化鉴定。
J Exp Med. 1980 Mar 1;151(3):709-15. doi: 10.1084/jem.151.3.709.
4
Complementation between a gene of the I-E subregion and a non-H-2 gene in the class-specific suppression of IgG2a antibody to sheep erythrocytes.I-E亚区的一个基因与一个非H-2基因在对绵羊红细胞IgG2a抗体的类别特异性抑制中的互补作用。
Immunogenetics. 1981;12(1-2):89-99. doi: 10.1007/BF01561653.
5
The H-Y antigen and its role in natural transplantation.H-Y抗原及其在自然移植中的作用。
Hum Genet. 1981;58(1):9-17. doi: 10.1007/BF00284141.
6
Growth of SJL/J-derived transplantable reticulum cell sarcoma as related to its ability to induce T-cell proliferation in the host. I. Dominant negative genetic influences of other parent haplotype in F1 hybrids of SJL/J mice.SJL/J 衍生的可移植性网状细胞肉瘤的生长与其在宿主体内诱导 T 细胞增殖能力的关系。I. SJL/J 小鼠 F1 杂交种中其他亲本单倍型的显性负性遗传影响。
J Exp Med. 1980 Feb 1;151(2):347-61. doi: 10.1084/jem.151.2.347.
7
Cytolytic T cells activated by H-2-controlled E molecules cross-react with A molecules.由H-2控制的E分子激活的细胞溶解性T细胞与A分子发生交叉反应。
Immunogenetics. 1982;15(5):519-27. doi: 10.1007/BF00345911.
8
Hybridoma monoclonal antibodies in the analysis of human cell surface antigens.杂交瘤单克隆抗体在人类细胞表面抗原分析中的应用
In Vitro. 1981 Dec;17(12):1051-7. doi: 10.1007/BF02618602.
9
Structure of murine Ia antigens. Two dimensional electrophoretic analyses and high pressure liquid chromatography tryptic peptide maps of products of the I-A and I-E subregions and of an associated invariant polypeptide.小鼠Ia抗原的结构。I-A和I-E亚区产物以及一种相关的恒定多肽的二维电泳分析和高压液相色谱胰蛋白酶肽图谱。
J Exp Med. 1981 Apr 1;153(4):936-50. doi: 10.1084/jem.153.4.936.
10
Variable synthesis and expression of E alpha and Ae (E beta) Ia polypeptide chains in mice of different H-2 haplotypes.不同H-2单倍型小鼠中Eα和Ae（Eβ）Ia多肽链的可变合成与表达
Immunogenetics. 1981;12(3-4):321-37. doi: 10.1007/BF01561674.

本文引用的文献

1
Histocompatibility-linked immune response genes.组织相容性连锁免疫反应基因
Science. 1972 Jan 21;175(4019):273-9. doi: 10.1126/science.175.4019.273.
2
Structural studies on the murine IA alloantigens. II. Molecular weight characterization of the products of the I-A and I-E/C subregions.小鼠IA同种异体抗原的结构研究。II. I-A和I-E/C亚区产物的分子量特征
J Immunol. 1978 Dec;121(6):2205-12.
3
Analysis of H-2 and Ia molecules by two-dimensional gel electrophoresis.通过二维凝胶电泳分析H-2和Ia分子。
J Exp Med. 1977 Nov 1;146(5):1261-79. doi: 10.1084/jem.146.5.1261.
4
Serological and functional evidence for further subdivision of the I regions of the H-2 gene complex.关于H-2基因复合体I区进一步细分的血清学及功能证据。
Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:477-87. doi: 10.1101/sqb.1977.041.01.055.
5
Studies on the protein products of murine chromosome 17:a status report.小鼠17号染色体蛋白质产物的研究：现状报告。
Transplant Proc. 1978 Dec;10(4):695-9.
6
Two-gene control of the expression of a murine Ia antigen.小鼠Ia抗原表达的双基因控制
J Exp Med. 1978 Oct 1;148(4):925-39. doi: 10.1084/jem.148.4.925.
7
Heavy HLA-DR (Ia) antigen chain is controlled by the MHC region.重型HLA - DR（Ia）抗原链由主要组织相容性复合体（MHC）区域控制。
Nature. 1978 Oct 26;275(5682):762-4. doi: 10.1038/275762a0.
8
Genetic control of specific immune responses and immune suppressions by I-region genes.I区基因对特异性免疫应答和免疫抑制的遗传控制。
Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:465-75. doi: 10.1101/sqb.1977.041.01.054.
9
Genetics and serology of HL-A-linked human Ia antigens.与HL - A相关的人类Ia抗原的遗传学和血清学
Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:443-55. doi: 10.1101/sqb.1977.041.01.052.
10
Structural and serological properties of murine Ia alloantigens.小鼠Ia同种异体抗原的结构和血清学特性。
Transplant Rev. 1976;30:236-70. doi: 10.1111/j.1600-065x.1976.tb00222.x.