小鼠Ia同种异体抗原的结构研究。V. I-E/Cβ多肽结构基因在I-A亚区内编码的证据。
Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion.
作者信息
Cook R G, Vitetta E S, Uhr J W, Capra J D
出版信息
J Exp Med. 1979 Apr 1;149(4):981-6. doi: 10.1084/jem.149.4.981.
Abstract
The E/C alpha- and beta-subunits of intra-I-region recombinants were analyzed for primary structural variation by comparative tryptic peptide mapping. The E/C alpha-polypeptides from B10.A, B10.A (3R) and B10.A (5R) showed complete coincident elution of peptides; the E/C beta-chains from B10.A and 3R (or 5R) were approximately 40% different. This suggests that the structural gene for the E/C beta-polypeptide is within the I-A subregion.
摘要
通过比较胰蛋白酶肽图谱分析I区内重组体的E/Cα和β亚基的一级结构变异。来自B10.A、B10.A（3R）和B10.A（5R）的E/Cα多肽显示出肽的完全一致洗脱；来自B10.A和3R（或5R）的E/Cβ链大约有40%的差异。这表明E/Cβ多肽的结构基因位于I-A亚区内。
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Histocompatibility-linked immune response genes.组织相容性连锁免疫反应基因
Science. 1972 Jan 21;175(4019):273-9. doi: 10.1126/science.175.4019.273.
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Analysis of H-2 and Ia molecules by two-dimensional gel electrophoresis.通过二维凝胶电泳分析H-2和Ia分子。
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Two-gene control of the expression of a murine Ia antigen.小鼠Ia抗原表达的双基因控制
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Heavy HLA-DR (Ia) antigen chain is controlled by the MHC region.重型HLA - DR（Ia）抗原链由主要组织相容性复合体（MHC）区域控制。
Nature. 1978 Oct 26;275(5682):762-4. doi: 10.1038/275762a0.
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