杂交Ia抗原的血清学和生化鉴定。
Serological and biochemical identification of hybrid Ia antigens.
作者信息
Lafuse W P, McCormick J F, David C S
出版信息
J Exp Med. 1980 Mar 1;151(3):709-15. doi: 10.1084/jem.151.3.709.
Abstract
Ia specificities 22 and 23 were found to be determinants on hybrid Ia molecules by serological and biochemical studies. Lipopolysaccharide-stimulated splenic lymphocytes from (B10 X B10.D2)F1 expressed Ia.22 although both the parents were negative. Similarly [D2.GD X B10.A(5R)]F1 cells expressed Ia.23, whereas D2.GD and B10.A(5R) lacked it. Ia.22 can be generated by gene complementation of Ak-Ek, Ab-Ed, Ab-Ek, As-Ed, and As-Ek, whereas Ia.23 can be generated by Ad-Ed, Ad-Ek, and Ad-Ep. Other possible complementing combinations are under study. The role of Ia.22 and 23 in mixed lymphocyte reactions and immune responses are discussed.
摘要
通过血清学和生化研究发现，Ia特异性22和23是杂交Ia分子的决定因素。来自（B10×B10.D2）F1的脂多糖刺激的脾淋巴细胞表达Ia.22，尽管双亲均为阴性。同样，[D2.GD×B10.A(5R)]F1细胞表达Ia.23，而D2.GD和B10.A(5R)则缺乏该分子。Ia.22可由Ak-Ek、Ab-Ed、Ab-Ek、As-Ed和As-Ek的基因互补产生，而Ia.23可由Ad-Ed、Ad-Ek和Ad-Ep产生。其他可能的互补组合正在研究中。文中讨论了Ia.22和23在混合淋巴细胞反应和免疫应答中的作用。
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本文引用的文献
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Two-gene control of the expression of a murine Ia antigen.小鼠Ia抗原表达的双基因控制
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