Hauschild A H, Niilo L, Dorward W J
Appl Microbiol. 1968 Aug;16(8):1235-9. doi: 10.1128/am.16.8.1235-1239.1968.
Clostridium perfringens type A suspended in fresh medium was injected into ligated intestinal loops of lambs. Within 7 hr after inoculation, the fluid volume of the loops increased up to seven times. No significant accumulation of fluid occurred in loops receiving grown culture, culture supernatant fluid, or medium alone. alpha-Antitoxin injected along with C. perfringens in fresh medium into intestinal loops did not prevent the accumulation of fluid. It is concluded that alpha-toxin plays no major role in C. perfringens type A enteritis.
将悬浮于新鲜培养基中的A型产气荚膜梭菌注入羔羊的结扎肠袢。接种后7小时内，肠袢中的液体量增加至7倍。接受培养物、培养上清液或单独培养基的肠袢中未出现明显的液体蓄积。将α抗毒素与新鲜培养基中的产气荚膜梭菌一起注入肠袢并不能阻止液体的蓄积。得出的结论是，α毒素在A型产气荚膜梭菌肠炎中不起主要作用。
