聚丙烯酸和聚甲基丙烯酸的抗病毒活性。I. 体外作用模式。
Antiviral activity of polyacrylic and polymethacrylic acids. I. Mode of action in vitro.
作者信息
De Somer P, De Clercq E, Billiau A, Schonne E, Claesen M
出版信息
J Virol. 1968 Sep;2(9):878-85. doi: 10.1128/JVI.2.9.878-885.1968.
Abstract
Polyacrylic acid (PAA) and polymethacrylic acid (PMAA) were investigated for their antiviral properties in tissue culture. Compared to other related polyanions, as dextran sulfate, polystyrene sulfonate, polyvinyl sulfate, and polyphloroglucinol phosphate, PAA and PMAA were found to be significantly more antivirally active and less cytotoxic. PMAA added 24 hr prior to virus inoculation inhibited viral growth most efficiently but it was still effective when added 3 hr after infection. Neither a direct irreversible action on the virus nor inhibition of virus penetration into the cell could explain the antiviral activity of PMAA. PMAA inhibited the adsorption of the virus to the host cell and suppressed the one-cycle viral synthesis in tissue cultures inoculated with infectious RNA.
摘要
研究了聚丙烯酸（PAA）和聚甲基丙烯酸（PMAA）在组织培养中的抗病毒特性。与其他相关聚阴离子，如硫酸葡聚糖、聚苯乙烯磺酸盐、聚乙烯硫酸盐和聚间苯三酚磷酸酯相比，发现PAA和PMAA具有显著更高的抗病毒活性且细胞毒性更小。在病毒接种前24小时添加PMAA能最有效地抑制病毒生长，但在感染后3小时添加仍有效。PMAA对病毒既没有直接的不可逆作用，也没有抑制病毒进入细胞，这无法解释其抗病毒活性。PMAA抑制病毒吸附到宿主细胞上，并抑制接种感染性RNA的组织培养中的单周期病毒合成。
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本文引用的文献
1
The combination of lysine polypeptides with tobacco mosaic virus.赖氨酸多肽与烟草花叶病毒的组合。
J Biol Chem. 1951 Nov;193(1):13-22.
2
Inhibitory effect of synthetic lysine polypeptides on growth of influenza virus in embryonated eggs.合成赖氨酸多肽对鸡胚中流感病毒生长的抑制作用。
Proc Soc Exp Biol Med. 1951 Apr;76(4):662-5. doi: 10.3181/00379727-76-18588.
3
PENETRATION OF HERPES SIMPLEX VIRUS INTO HUMAN EPIDERMOID CELLS.单纯疱疹病毒对人表皮细胞的穿透作用
Proc Soc Exp Biol Med. 1964 Aug-Sep;116:863-9. doi: 10.3181/00379727-116-29392.
4
STARCH GEL AS AN OVERLAY FOR THE PLAQUE ASSAY OF ANIMAL VIRUSES.淀粉凝胶作为动物病毒蚀斑测定的覆盖物
Virology. 1964 Sep;24:13-8. doi: 10.1016/0042-6822(64)90142-4.
5
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6
THE EARLY INTERACTION OF ANIMAL VIRUSES AND CELLS.动物病毒与细胞的早期相互作用
Prog Med Virol. 1963;5:43-78.
7
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8
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9
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10
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Ann Med Exp Biol Fenn. 1962;40:334-41.
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