Innis S M, Clandinin M T
J Nutr. 1980 May;110(5):1006-13. doi: 10.1093/jn/110.5.1006.
Experiments were conducted to determine if regression of cardiac lipidosis and strain or sex differences in susceptibility to cardiopathological change induced by rapeseed oils are coincident with physiological differences in fatty acid substrates supplied to the heart. Plasma fatty acid composition was determined in male Sprague-Dawley rats after 7 or 28 days and in female Sprague-Dawley and male Chester-Beatty rats after 28 days of feeding high or low erucic acid rapeseed oils, soybean oil or peanut oil. After 28 days, C14:0 and C18:1 fell and C20:4 increased as a percent of total fatty acid in all animals irrespective of oil fed, suggesting that changes in plasma fatty acids normally occur with development. Saturated and essential fatty acid profiles of male and female rats were different. Differences in plasma fatty acids stemming from sex-related physiological differences in whole body fat metabolism may form the basis of lower cardiopathological involvement for females. Results suggest physiological differences unrelated to plasma fatty acids determine strain differences in timing and severity of rapeseed oil-induced cardiac pathology.
进行实验以确定心脏脂质沉积的消退以及菜籽油诱导的心脏病理变化易感性中的品系或性别差异是否与供应给心脏的脂肪酸底物的生理差异一致。在雄性Sprague-Dawley大鼠喂食7天或28天后，以及雌性Sprague-Dawley大鼠和雄性Chester-Beatty大鼠喂食高芥酸或低芥酸菜籽油、大豆油或花生油28天后，测定血浆脂肪酸组成。28天后，无论喂食何种油类，所有动物中C14:0和C18:1占总脂肪酸的百分比下降，C20:4增加，这表明血浆脂肪酸的变化通常随发育而发生。雄性和雌性大鼠的饱和脂肪酸和必需脂肪酸谱不同。全身脂肪代谢中与性别相关的生理差异导致的血浆脂肪酸差异可能是女性心脏病理受累程度较低的基础。结果表明，与血浆脂肪酸无关的生理差异决定了菜籽油诱导的心脏病理在时间和严重程度上的品系差异。
