• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

组蛋白磷酸化：由3',5'-单磷酸腺苷刺激产生。

Histone phosphorylation: stimulation by adenosine 3',5'-monophosphate.

作者信息

Langan T A

出版信息

Science. 1968 Nov 1;162(3853):579-80. doi: 10.1126/science.162.3853.579.

DOI:10.1126/science.162.3853.579
PMID:4303296
Abstract

Adenosine cyclic 3',5'-monophosphate at a concentration of 10-(7)M causes a four-to sixfold increase in the rate of histone phosphorylation catalyzed by a liver enzyme preparation. This observation suggests a mechanism for the induction of RNA synthesis by those hormones that cause increases in the concentration of cyclic AMP.

摘要

浓度为10⁻⁷M的环磷腺苷酸可使肝脏酶制剂催化的组蛋白磷酸化速率提高4至6倍。这一观察结果提示了一种机制，即那些导致环磷腺苷酸浓度升高的激素可诱导RNA合成。

相似文献

1
Histone phosphorylation: stimulation by adenosine 3',5'-monophosphate.组蛋白磷酸化：由3',5'-单磷酸腺苷刺激产生。
Science. 1968 Nov 1;162(3853):579-80. doi: 10.1126/science.162.3853.579.
2
Action of adenosine 3',5'-monophosphate-dependent histone kinase in vivo.环磷酸腺苷依赖性组蛋白激酶的体内作用
J Biol Chem. 1969 Oct 25;244(20):5763-5.
3
Adenosine 3',5'-monophosphate-dependent protein kinase from brain.来自大脑的3',5'-环磷酸腺苷依赖性蛋白激酶
Science. 1968 Jul 4;165(3888):63-5.
4
Control of histone modification within chromatin by adenine nucleotides and steroid hormones.腺嘌呤核苷酸和类固醇激素对染色质中组蛋白修饰的调控。
Biochem J. 1971 Jul;123(4):37P. doi: 10.1042/bj1230037p.
5
Phosphorylation of histones in vivo under the control of cyclic AMP and hormones.
Adv Biochem Psychopharmacol. 1970;3:307-23.
6
The enhancement of phosphoryl transfer by adenosine 3',5'-monophosphate in the presence of a membranous fraction from canine kidney.在存在犬肾膜组分的情况下，3',5'-单磷酸腺苷对磷酸转移的增强作用。
Biochim Biophys Acta. 1968 Oct 15;165(3):574-7. doi: 10.1016/0304-4165(68)90248-1.
7
Phosphorylation of rat liver ribosomal subunits: partial purification of two cyclic AMP activated protein kinases.
Biochem Biophys Res Commun. 1971 Jun 4;43(5):1001-9. doi: 10.1016/0006-291x(71)90561-4.
8
Effects of cyclic 3',5'-adenosine monophosphate and dibutyryl cyclic 3',5'-adenosine monophosphate on basal and stimulated thyroid function.环磷腺苷和双丁酰环磷腺苷对基础及刺激状态下甲状腺功能的影响
J Clin Endocrinol Metab. 1968 Dec;28(12):1816-23. doi: 10.1210/jcem-28-12-1816.
9
Adenosine 3', 5'-monophosphate and histone phosphorylation during enzyme induction by glucagon in rat liver.大鼠肝脏中胰高血糖素诱导酶过程中的3',5'-环磷酸腺苷与组蛋白磷酸化
J Biochem. 1973 Mar;73(3):621-9. doi: 10.1093/oxfordjournals.jbchem.a130120.
10
Role of cyclic adenosine 3',5'-monophosphate in the induction of hepatic enzymes. II. Effect of N6,O2'-dibutyryl cyclic adenosine 3'-5'-monophosphate on the kinetics of ribonucleic acid synthesis in purified rat liver nuclei.环磷酸腺苷在肝酶诱导中的作用。II. N6,O2'-二丁酰环磷酸腺苷对纯化大鼠肝细胞核中核糖核酸合成动力学的影响。
J Biol Chem. 1971 Mar 25;246(6):1623-9.

引用本文的文献

1
Diverse and dynamic forms of gene regulation by the S. cerevisiae histone methyltransferase Set1.酿酒酵母组蛋白甲基转移酶 Set1 的多种动态基因调控形式。
Curr Genet. 2023 Jun;69(2-3):91-114. doi: 10.1007/s00294-023-01265-3. Epub 2023 Mar 31.
2
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study.代谢性疾病中的表观遗传调控：机制及临床研究进展。
Signal Transduct Target Ther. 2023 Mar 2;8(1):98. doi: 10.1038/s41392-023-01333-7.
3
Metabolic reprogramming and epigenetic modifications on the path to cancer.
癌症发生过程中的代谢重编程和表观遗传修饰。
Protein Cell. 2022 Dec;13(12):877-919. doi: 10.1007/s13238-021-00846-7. Epub 2021 May 29.
4
Histone modifiers in cancer: friends or foes?癌症中的组蛋白修饰因子：是友还是敌？
Genes Cancer. 2011 Jun;2(6):631-47. doi: 10.1177/1947601911417176.
5
Dynamic interplay between histone H3 modifications and protein interpreters: emerging evidence for a "histone language".组蛋白 H3 修饰与蛋白解读器之间的动态相互作用：“组蛋白语言”的新证据
Chembiochem. 2011 Jan 24;12(2):299-307. doi: 10.1002/cbic.201000474. Epub 2010 Oct 29.
6
Enhanced phosphorylation of high-mobility-group proteins in nuclease-sensitive mononucleosomes from butyrate-treated HeLa cells.丁酸盐处理的HeLa细胞中核酸酶敏感单核小体中高迁移率族蛋白的磷酸化增强。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2189-93. doi: 10.1073/pnas.78.4.2189.
7
Phosphorylation of H1 histones.H1组蛋白的磷酸化
Mol Cell Biochem. 1983;57(1):81-92. doi: 10.1007/BF00223526.
8
Sponge cell aggregation.海绵细胞聚集。
Mol Cell Biochem. 1980 Feb 28;29(3):131-43. doi: 10.1007/BF00420285.
9
Protein-hormonal complexes of the hypothalamus as neurochemical systems of regulation.作为调节神经化学系统的下丘脑蛋白质-激素复合物
Neurochem Res. 1983 Dec;8(12):1511-35. doi: 10.1007/BF00964154.
10
Histone F1 from rat thymus. Subfractionation and incorporation of [32P] phosphate in vitro.来自大鼠胸腺的组蛋白F1。体外亚分级分离及[32P]磷酸盐掺入
Biochem J. 1970 Apr;117(3):509-12. doi: 10.1042/bj1170509.