抗组胺药。1. 2-（酰氨基）恶唑类。
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
作者信息
Ross W J, Harrison R G, Jolley M R, Neville M C, Todd A, Verge J P, Dawson W, Sweatman W J
出版信息
J Med Chem. 1979 Apr;22(4):412-7. doi: 10.1021/jm00190a011.
PMID:430478
Abstract
The synthesis and biological properties of 35 2-(acylamino)oxazoles are described. The majority of the compounds inhibit the release of slow-reacting substance of anaphylaxis (SRS-A) in vitro from sensitized guinea pig chopped lung. In addition, several of the compounds inhibited the release of SRS-A from passively sensitized human chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test.
摘要
描述了35种2-(酰氨基)恶唑的合成及其生物学特性。大多数化合物在体外能抑制致敏豚鼠肺匀浆中过敏反应慢反应物质(SRS-A)的释放。此外，其中几种化合物还能抑制被动致敏的人肺匀浆中SRS-A的释放，并在改良的赫克斯海默试验中保护豚鼠免受过敏反应的影响。
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