放线菌素D对冠状病毒229E复制的抑制作用。
Inhibition of coronavirus 229E replication by actinomycin D.
作者信息
Kennedy D A, Johnson-Lussenburg C M
出版信息
J Virol. 1979 Jan;29(1):401-4. doi: 10.1128/JVI.29.1.401-404.1979.
Abstract
The yields of human coronavirus 229E grown in L132 cells were markedly inhibited by actinomycin D, the 50% inhibitory dose being 0.1 micron/ml. Inhibition was maximal during the early phase of virus replication, did not appear to involve viral RNA synthesis per se, and was shown to be dependent on the input multiplicity of infection.
摘要
在L132细胞中培养的人冠状病毒229E的产量受到放线菌素D的显著抑制，50%抑制剂量为0.1微克/毫升。在病毒复制的早期阶段抑制作用最大，似乎不涉及病毒RNA的合成本身，并且显示出依赖于感染的输入复数。
相似文献
1
Inhibition of coronavirus 229E replication by actinomycin D.放线菌素D对冠状病毒229E复制的抑制作用。
J Virol. 1979 Jan;29(1):401-4. doi: 10.1128/JVI.29.1.401-404.1979.
2
Differential in vitro inhibition of feline enteric coronavirus and feline infectious peritonitis virus by actinomycin D.放线菌素D对猫肠道冠状病毒和猫传染性腹膜炎病毒的体外差异抑制作用
J Gen Virol. 1992 Dec;73 ( Pt 12):3285-8. doi: 10.1099/0022-1317-73-12-3285.
3
Inhibition of the growth of human coronavirus 229E by leupeptin.亮抑蛋白酶肽对人冠状病毒229E生长的抑制作用。
J Gen Virol. 1985 Feb;66 ( Pt 2):363-6. doi: 10.1099/0022-1317-66-2-363.
4
Inhibition of measles virus replication and RNA synthesis by actinomycin D.放线菌素D对麻疹病毒复制和RNA合成的抑制作用。
Biochem Biophys Res Commun. 1972 Aug 7;48(3):657-61. doi: 10.1016/0006-291x(72)90398-1.
5
Establishment and maintenance of a persistent infection of L132 cells by human coronavirus strain 229E.人冠状病毒229E对L132细胞持续感染的建立与维持
Arch Virol. 1981;69(2):117-29. doi: 10.1007/BF01315155.
6
Effect of ultraviolet irradiation and actinomycin D on polyoma virus replication in mouse embryo cell cultures.紫外线照射和放线菌素D对小鼠胚胎细胞培养中多瘤病毒复制的影响。
J Virol. 1969 Jun;3(6):570-7. doi: 10.1128/JVI.3.6.570-577.1969.
7
[Influence of actinomycin D on the effectiveness of producing ts mutants of the Japanese encephalitis virus].[放线菌素D对日本脑炎病毒温度敏感突变株产生效率的影响]
Vopr Virusol. 1988 May-Jun;33(3):335-8.
8
Characteristics of a long term in vitro persistent infection with human coronavirus 229E.人冠状病毒229E的长期体外持续感染特征
Adv Exp Med Biol. 1981;142:309-22. doi: 10.1007/978-1-4757-0456-3_25.
9
Inhibition of Pichinde virus replication by actinomycin D.放线菌素D对皮钦德病毒复制的抑制作用。
J Gen Virol. 1976 Dec;33(3):421-34. doi: 10.1099/0022-1317-33-3-421.
10
Substitution in the poliovirus replicase gene determines actinomycin D sensitivity of viral replication at elevated temperature.
Virus Res. 1989 Jan;12(1):19-32. doi: 10.1016/0168-1702(89)90050-6.
引用本文的文献
1
Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection.天然存在的生物活性物质作为抗病毒剂：重点关注冠状病毒感染
Front Pharmacol. 2021 Jun 29;12:575877. doi: 10.3389/fphar.2021.575877. eCollection 2021.
2
Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2-ACE2 Receptor Interactions.多学科方法鉴定与人 ACE2 或 SARS-CoV-2 刺突蛋白结合的化合物，作为阻断 SARS-CoV-2-ACE2 受体相互作用的候选药物。
mBio. 2021 Mar 30;12(2):e03681-20. doi: 10.1128/mBio.03681-20.
3
Repurposing anticancer drugs for the management of COVID-19.重新利用抗癌药物来治疗新冠肺炎。
Eur J Cancer. 2020 Dec;141:40-61. doi: 10.1016/j.ejca.2020.09.014. Epub 2020 Sep 22.
4
The pathogenesis of Rift Valley fever.裂谷热的发病机制。
Viruses. 2011 May;3(5):493-519. doi: 10.3390/v3050493.
5
The molecular biology of coronaviruses.冠状病毒的分子生物学
Adv Virus Res. 2006;66:193-292. doi: 10.1016/S0065-3527(06)66005-3.
6
The molecular biology of coronaviruses.冠状病毒的分子生物学
Adv Virus Res. 1997;48:1-100. doi: 10.1016/S0065-3527(08)60286-9.
7
The replication of murine coronaviruses in enucleated cells.鼠冠状病毒在去核细胞中的复制。
Virology. 1981 Apr 15;110(1):225-30. doi: 10.1016/0042-6822(81)90027-1.
8
Coronavirus multiplication strategy. I. Identification and characterization of virus-specified RNA.冠状病毒增殖策略。I. 病毒特异性RNA的鉴定与表征
J Virol. 1980 Jun;34(3):665-74. doi: 10.1128/JVI.34.3.665-674.1980.
9
The coronavirus avian infectious bronchitis virus requires the cell nucleus and host transcriptional factors.冠状病毒禽传染性支气管炎病毒需要细胞核和宿主转录因子。
Virology. 1980 Sep;105(2):582-91. doi: 10.1016/0042-6822(80)90058-6.
10
Replication and morphogenesis of avian coronavirus in Vero cells and their inhibition by monensin.禽冠状病毒在Vero细胞中的复制与形态发生及其被莫能菌素的抑制作用
Virus Res. 1984;1(2):153-67. doi: 10.1016/0168-1702(84)90070-4.
本文引用的文献
1
OBSERVATIONS ON THE GROWTH OF MOUSE HEPATITIS VIRUS (MHV-3) IN MOUSE MACROPHAGES.小鼠巨噬细胞中鼠肝炎病毒（MHV-3）生长情况的观察
Virology. 1965 Jan;25:30-7. doi: 10.1016/0042-6822(65)90248-5.
2
The measurement of radioactive precursor incorporation into small monolayer cultures.放射性前体掺入小型单层培养物的测量。
Methods Cell Biol. 1973;7:349-60. doi: 10.1016/s0091-679x(08)61786-0.
3
Ribonucleic acid synthesis in porcine cell cultures infected with transmissible gastroenteritis virus.感染传染性胃肠炎病毒的猪细胞培养物中的核糖核酸合成
Am J Vet Res. 1973 Feb;34(2):185-8.
4
The effect of 5-bromodoxyuridine and actinomycin D on the multiplication of transmissible gastroenteritis virus.5-溴脱氧尿苷和放线菌素D对传染性胃肠炎病毒增殖的影响。
J Gen Virol. 1968 Sep;3(2):267-70. doi: 10.1099/0022-1317-3-2-267.
5
Rat coronavirus (RCV): a prevalent, naturally occurring pneumotropic virus of rats.大鼠冠状病毒（RCV）：一种在大鼠中普遍存在的、自然发生的嗜肺病毒。
Arch Gesamte Virusforsch. 1970;31(3):293-302. doi: 10.1007/BF01253764.
6
Isolation and morphology of the internal component of human coronavirus, strain 229E.人冠状病毒229E株内部成分的分离与形态学研究
Intervirology. 1975;6(4-5):197-206. doi: 10.1159/000149474.
7
Presence of genomic polyadenylate and absence of detectable virion transcriptase in human coronavirus OC-43.
J Gen Virol. 1978 Apr;39(1):29-39. doi: 10.1099/0022-1317-39-1-29.
8
RNA of mouse hepatitis virus.小鼠肝炎病毒的核糖核酸
J Virol. 1978 May;26(2):236-42. doi: 10.1128/JVI.26.2.236-242.1978.
9
Biological properties of avian coronavirus RNA.禽冠状病毒RNA的生物学特性
J Gen Virol. 1977 Sep;36(3):531-3. doi: 10.1099/0022-1317-36-3-531.
10
The characterisation of the virion RNA of avian infectious bronchitis virus.禽传染性支气管炎病毒病毒粒子RNA的特性
FEBS Lett. 1977 May 15;77(2):311-3. doi: 10.1016/0014-5793(77)80258-5.
Zotero 插件