Albert D M, Rabson A S, Grimes P A, Von Sallmann L
Science. 1969 May 30;164(3883):1077-8. doi: 10.1126/science.164.3883.1077.
Hamster lens epithelium infected with simian virus 40 underwent transformation in vitro and produced tumors when injected into homologous hosts. Undisturbed lens epithelium in man and experimental animals has not been observed to undergo neoplastic change. The virus-induced tumors contained undifferentiated cells that were either polygonal or spindle-shaped. Their origin from lens epithelium seems certain since it is possible to isolate this unique structure free of connective tissue and blood vessels.
感染了猴病毒40的仓鼠晶状体上皮细胞在体外发生转化，并在注射到同源宿主中时产生肿瘤。在人类和实验动物中，未观察到未受干扰的晶状体上皮细胞发生肿瘤性变化。病毒诱导的肿瘤含有未分化的细胞，这些细胞要么是多边形的，要么是纺锤形的。它们起源于晶状体上皮似乎是确定的，因为有可能分离出这种不含结缔组织和血管的独特结构。
