Kim Y D, Lees D E, Lake C R, Whang-Peng J, Schuette W, Smith R, Bull J
JAMA. 1979 Apr 27;241(17):1816-7.
The intercurrent administration of doxorubicin hydrochloride to a patient undergoing whole-body hyperthermia for the treatment of metastatic cancer repeatedly produced ventricular irritability and cardiac dysfunction. Individually, doxorubicin and hyperthermia were tolerated by the patient without incident. Catecholamine determinations showed that the administration of doxorubicin under hyperthermic conditions increased the liberation of both epinephrine and norepinephrine. The acute synergistic cardiotoxic effects occurred with doxorubicin dosages that were severalfold less than those associated with only mild and transient ECG disturbances under normothermic conditions.
在一名接受全身热疗以治疗转移性癌症的患者中，同时给予盐酸多柔比星反复引发心室应激性和心脏功能障碍。单独使用时，患者耐受多柔比星和热疗，未出现不良事件。儿茶酚胺测定表明，在热疗条件下给予多柔比星会增加肾上腺素和去甲肾上腺素的释放。急性协同心脏毒性作用发生时，多柔比星的剂量比在正常体温条件下仅引起轻度和短暂心电图异常的剂量低几倍。
