黄热病疫苗。II. 不含禽白血病病毒的疫苗种子的抗原性和神经毒力。
Yellow fever vaccine. II. Antigenicity and neurovirulence of a vaccine seed free from avian leukosis virus.
作者信息
Tauraso N M, Spector S L, Kirschstein R L, Seligmann E B, Farber J F
出版信息
Appl Microbiol. 1969 Jun;17(6):866-70. doi: 10.1128/am.17.6.866-870.1969.
Abstract
Avian leukosis virus (ALV)-free candidate primary and secondary seed lots were indistinguishable from corresponding ALV-contaminated lots with respect to (i) potency as measured by titration in newborn and weanling mice and in the MA-104 plaque system, (ii) degree of viscerotropism as measured by viremia in monkeys, (iii) neurotropism as determined by the monkey neurovirulence test, and (iv) potency as determined by antibody response in monkeys inoculated by the intracerebral route.
摘要
无禽白血病病毒（ALV）的候选原代和传代种子批，在以下方面与相应的受ALV污染的批次没有区别：（i）通过在新生和断奶小鼠以及MA - 104空斑系统中滴定测量的效力；（ii）通过猴子病毒血症测量的嗜内脏性程度；（iii）通过猴子神经毒力试验确定的嗜神经性；以及（iv）通过脑内接种猴子后的抗体反应确定的效力。
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