Morris H R, Taylor G W, Piper P J, Tippins J R
Agents Actions Suppl. 1979(6):27-36. doi: 10.1007/978-3-0348-7232-4_3.
We have demonstrated the role of arachidonic acid and lipoxygenase in the genesis of SRS-A and the possible role of lipoxygenases in its metabolism. SRS-A has been purified in microgram quantities together with closely related material. We have identified 5,12 di-hydroxy-6, 8, 10, 14 eicosatetranenoic acid released by antigen challenge, and which we feel is related to SRS-A. Further structural work is in progress.
我们已经证明了花生四烯酸和脂氧合酶在慢反应物质-A（SRS-A）生成中的作用，以及脂氧合酶在其代谢中的可能作用。SRS-A已与密切相关物质一起以微克量纯化出来。我们已经鉴定出抗原激发后释放的5,12-二羟基-6,8,10,14-二十碳四烯酸，我们认为它与SRS-A有关。进一步的结构研究正在进行中。
