正常肝脏和诺维科夫肝癌的转运RNA差异。
Differences in the transfer RNA's of normal liver and Novikoff hepatoma.
作者信息
Baliga B S, Borek E, Weinstein I B, Srinivasan P R
出版信息
Proc Natl Acad Sci U S A. 1969 Mar;62(3):899-905. doi: 10.1073/pnas.62.3.899.
Abstract
-A comparison of the elution profiles of 18 aminoacyl-tRNA's from Novikoff hepatoma with those from normal liver on a methylated albuminkieselguhr column revealed the occurrence of new species of tRNA for histidine, tyrosine, and asparagine in the hepatoma. In addition, the hepatoma tRNA's for arginine, isoleucine, lysine, methionine, serine, alanine, and tryptophan eluted at a higher salt concentration than the corresponding tRNA's of normal liver. The remaining eight amino acids did not show any significant differences in the elution profiles.
摘要
- 在甲基化白蛋白硅藻土柱上，对来自诺维科夫肝癌的18种氨酰基转移核糖核酸（tRNA）与来自正常肝脏的tRNA的洗脱图谱进行比较，结果显示肝癌中出现了组氨酸、酪氨酸和天冬酰胺tRNA的新种类。此外，肝癌中精氨酸、异亮氨酸、赖氨酸、甲硫氨酸、丝氨酸、丙氨酸和色氨酸的tRNA在比正常肝脏相应tRNA更高的盐浓度下洗脱。其余8种氨基酸在洗脱图谱中未显示出任何显著差异。
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