Stewart W E, Scott W D, Sulkin S E
J Virol. 1969 Aug;4(2):147-53. doi: 10.1128/JVI.4.2.147-153.1969.
Some viruses were found to be more sensitive than others to the action of interferons from certain species of animals but less sensitive to interferons from other species. Vaccinia virus was the most sensitive to mouse and hamster interferons of five viruses tested, but the least sensitive of these five viruses to human, rabbit, and bat interferons. The relative sensitivities of the viruses to interferons were found to be characteristic for each of the species tested, with those closely related phylogenetically exhibiting similar patterns of relative interferon-induced virus resistance. The amount of synthetic double-stranded polynucleotide polyinosinic acid-polycytidylic acid required to induce resistance to each of the viruses in each of the cell species correlated with the interferon sensitivities of the viruses.
人们发现,某些病毒对来自动物某些物种的干扰素作用比其他病毒更敏感,但对来自其他物种的干扰素则不太敏感。在测试的五种病毒中,痘苗病毒对小鼠和仓鼠干扰素最敏感,但对人、兔和蝙蝠干扰素最不敏感。已发现这些病毒对干扰素的相对敏感性是每个测试物种所特有的,在系统发育上密切相关的物种表现出相似的相对干扰素诱导病毒抗性模式。在每种细胞类型中诱导对每种病毒产生抗性所需的合成双链多核苷酸聚肌苷酸 - 聚胞苷酸的量与病毒的干扰素敏感性相关。