大鼠和小鼠中L-天冬酰胺酶活性的调节。正常生长与恶性生长、性别及饮食变化的影响。
The regulation of L-asparaginase activity in rats and mice. Effects of normal and malignant growth, of sex and of dietary changes.
作者信息
Bonetti E, Abbondanza A, Della Corte E, Stirpe F
出版信息
Biochem J. 1969 Nov;115(3):597-601. doi: 10.1042/bj1150597.
Abstract
- The activity of l-asparaginase was very low in the liver of newborn rats and mice, and increased within a few days of birth. 2. In rats, but not in mice, the enzyme activity was higher in females than in males, was enhanced by administration of oestradiol, and was decreased by gonadectomy. 3. The enzyme activity decreased in mice starved or fed on a low-protein diet; in rats it was enhanced by starvation, by feeding them on a high-protein diet, or by administration of l-asparagine. 4. The asparaginase activity was decreased in regenerating liver, and was almost absent in the Morris hepatoma 5123.
摘要
- L-天冬酰胺酶在新生大鼠和小鼠肝脏中的活性非常低，出生后几天内活性增加。2. 在大鼠中，而非小鼠，该酶活性雌性高于雄性，给予雌二醇可增强其活性，去势则使其活性降低。3. 饥饿或喂食低蛋白饮食的小鼠中该酶活性降低；在大鼠中，饥饿、喂食高蛋白饮食或给予L-天冬酰胺可增强其活性。4. 再生肝脏中天冬酰胺酶活性降低，在莫里斯肝癌5123中几乎不存在。
相似文献
1
The regulation of L-asparaginase activity in rats and mice. Effects of normal and malignant growth, of sex and of dietary changes.大鼠和小鼠中L-天冬酰胺酶活性的调节。正常生长与恶性生长、性别及饮食变化的影响。
Biochem J. 1969 Nov;115(3):597-601. doi: 10.1042/bj1150597.
2
3
[Study of glutaminase and asparaginase activities in normal tissues and malignant tumors].[正常组织和恶性肿瘤中谷氨酰胺酶和天冬酰胺酶活性的研究]
Ukr Biokhim Zh. 1966;38(5):484-9.
4
Regeneration, tumor, dietary, and L-asparaginase effects on asparagine biosynthesis in rat liver.再生、肿瘤、饮食及L-天冬酰胺酶对大鼠肝脏中天冬酰胺生物合成的影响。
Cancer Res. 1969 Jun;29(6):1179-83.
5
Effect of dietary asparagine and protein-equivalents in crystalline amino acid diets on asparagine metabolism in chicks.晶体氨基酸日粮中膳食天冬酰胺和蛋白质当量对雏鸡天冬酰胺代谢的影响。
J Nutr. 1981 Oct;111(10):1749-56. doi: 10.1093/jn/111.10.1749.
6
Partial purification, properties and regulation of inosine 5'phosphate dehydrogenase in normal and malignant rat tissues.正常和恶性大鼠组织中肌苷5'-磷酸脱氢酶的部分纯化、性质及调控
Biochem J. 1977 Jul 15;166(1):1-10. doi: 10.1042/bj1660001.
7
8
Asparagine metabolism in chicks and rats.雏鸡和大鼠体内的天冬酰胺代谢
Poult Sci. 1980 May;59(5):1109-13. doi: 10.3382/ps.0591109.
9
gamma-Glutamyltranspeptidase activity in normal, regenerating and malignant hepatocytes.正常、再生及恶性肝细胞中的γ-谷氨酰转肽酶活性
FEBS Lett. 1978 Jan 15;85(2):310-2. doi: 10.1016/0014-5793(78)80480-3.
10
Hypoxanthine phosphoribosyltransferase activity in normal, developing, and neoplastic tissues of the rat.大鼠正常、发育中和肿瘤组织中的次黄嘌呤磷酸核糖基转移酶活性
Eur J Cancer (1965). 1975 Jul;11(7):463-72. doi: 10.1016/0014-2964(75)90147-4.
引用本文的文献
1
The distribution of L-asparagine synthetase in the principal organs of several mammalian and avian species.L-天冬酰胺合成酶在几种哺乳动物和鸟类主要器官中的分布。
Biochem J. 1974 Jul;142(1):27-35. doi: 10.1042/bj1420027.
本文引用的文献
1
REGULATION OF XANTHINE DEHYDROGENASE IN CHICK LIVER. EFFECT OF STARVATION AND OF ADMINISTRATION OF PURINES AND PURINE NUCLEOSIDES.鸡肝脏中黄嘌呤脱氢酶的调节。饥饿以及嘌呤和嘌呤核苷给药的影响。
Biochem J. 1965 Feb;94(2):309-13. doi: 10.1042/bj0940309.
2
3
Turnover of rat liver arginase.大鼠肝脏精氨酸酶的周转
Ann N Y Acad Sci. 1963 Jan 21;102:587-601. doi: 10.1111/j.1749-6632.1963.tb13662.x.
4
Leukaemia-inhibiting properties and L-asparaginase activity of sera from certain South American rodents.某些南美啮齿动物血清的白血病抑制特性及L-天冬酰胺酶活性
Nature. 1963 May 25;198:801. doi: 10.1038/198801a0.
5
6
The determination of ammonia in whole blood by a direct colorimetric method.用直接比色法测定全血中的氨。
Clin Chim Acta. 1967 Aug;17(2):297-304. doi: 10.1016/0009-8981(67)90133-7.
7
Enzymes in cancer. Asparaginase from chicken liver.癌症中的酶。来自鸡肝的天冬酰胺酶。
Biochem J. 1967 Apr;103(1):238-45. doi: 10.1042/bj1030238.
8
Observations on respiratory decline in the pre-necrotic phase of dietary liver necrosis.关于饮食性肝坏死坏死前期呼吸功能衰退的观察
J Nutr. 1966 Dec;90(4):387-94. doi: 10.1093/jn/90.4.387.
9
Embryotoxic effect of L-asparaginase.L-天冬酰胺酶的胚胎毒性作用。
Nature. 1968 Jun 22;218(5147):1164-5. doi: 10.1038/2181164a0.
10
L-asparaginase: inhibition of early mitosis in regenerating rat liver.L-天冬酰胺酶：对再生大鼠肝脏早期有丝分裂的抑制作用
Science. 1967 Jun 23;156(3782):1602-3. doi: 10.1126/science.156.3782.1602.
Zotero 插件