Hancock R, Weil R
Proc Natl Acad Sci U S A. 1969 Aug;63(4):1144-50. doi: 10.1073/pnas.63.4.1144.
It was shown earlier that in cultures of contact-inhibited mouse kidney cells infection with polyoma virus induces replication of the chromosomal DNA. In this paper we present evidence, based on analyses of isolated chromatin, that, parallel with and as a consequence of the virus-induced synthesis of cellular DNA, the chromosomal proteins are synthesized in the proportions characteristic of normal chromosome replication. These results are compatible with the hypothesis that polyoma virus activates (or derepresses) a regulatory system of the host cell which controls initiation of chromosome replication.
先前的研究表明,在接触抑制的小鼠肾细胞培养物中,多瘤病毒感染会诱导染色体DNA的复制。在本文中,我们基于对分离染色质的分析提出证据,即与病毒诱导的细胞DNA合成同时并作为其结果,染色体蛋白以正常染色体复制特有的比例合成。这些结果与多瘤病毒激活(或解除抑制)宿主细胞中控制染色体复制起始的调节系统这一假设相符。