Weil R, Kára J
Proc Natl Acad Sci U S A. 1970 Oct;67(2):1011-7. doi: 10.1073/pnas.67.2.1011.
We have studied the temporal relationship between the appearance of polyoma-specific "tumor antigen" and polyoma-induced activation of the cellular DNA-synthesizing apparatus in "contact-inhibited" mouse-kidney tissue-culture cells. The experimental results are compatible with the hypothesis that virus-induced replication of the mouse cell chromosomes, which accompanies the actual production of progeny virus, is triggered by the tumor antigen. On the basis of the experimental evidence at present available we propose a tentative scheme of the lytic cycle of polyoma virus, that is of the events which lead to and accompany the production of polyoma progeny virus.
我们研究了多瘤特异性“肿瘤抗原”的出现与多瘤在“接触抑制”的小鼠肾组织培养细胞中诱导细胞DNA合成装置激活之间的时间关系。实验结果与以下假设相符：伴随子代病毒实际产生的小鼠细胞染色体的病毒诱导复制是由肿瘤抗原触发的。根据目前可得的实验证据，我们提出了一个多瘤病毒裂解周期的暂定方案，即导致并伴随多瘤子代病毒产生的一系列事件。
