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1
Transport of reduced nicotinamide-adenine dinucleotide into mitochondria of rat white adipose tissue.还原型烟酰胺腺嘌呤二核苷酸转运至大鼠白色脂肪组织线粒体的过程。
Biochem J. 1970 Jan;116(2):229-33. doi: 10.1042/bj1160229.
2
Flow of reducing equivalents into isolated intestinal mitochondria.还原当量流入分离的肠线粒体的过程。
Metabolism. 1979 Feb;28(2):105-12. doi: 10.1016/0026-0495(79)90075-1.
3
The role of the cytoplasmic redox potential in the control of fatty acid synthesis from glucose, pyruvate and lactate in white adipose tissue.细胞质氧化还原电位在白色脂肪组织中由葡萄糖、丙酮酸和乳酸合成脂肪酸的调控中的作用。
Biochem J. 1970 Jan;116(2):235-40. doi: 10.1042/bj1160235.
4
Glutamate and aspartate transport in rat brain mitochondria.大鼠脑线粒体中的谷氨酸和天冬氨酸转运
Biochem J. 1974 May;140(2):205-10. doi: 10.1042/bj1400205.
5
Oxidation of reduced cytosolic nicotinamide adenine dinucleotide by the malate-aspartate shuttle in the K-562 human leukemia cell line.苹果酸-天冬氨酸穿梭对K-562人白血病细胞系中还原型胞质烟酰胺腺嘌呤二核苷酸的氧化作用
Cancer Res. 1986 Nov;46(11):5589-91.
6
Control of the transport of reducing equivalents across the mitochondrial membrane in perfused rat heart.灌注大鼠心脏中线粒体膜上还原当量转运的调控。
J Mol Cell Cardiol. 1971 Jun;2(2):111-24. doi: 10.1016/0022-2828(71)90065-4.
7
Isolated durum wheat and potato cell mitochondria oxidize externally added NADH mostly via the malate/oxaloacetate shuttle with a rate that depends on the carrier-mediated transport.分离出的硬粒小麦和马铃薯细胞线粒体主要通过苹果酸/草酰乙酸穿梭途径氧化外源添加的NADH，其氧化速率取决于载体介导的转运。
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8
Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools.用于还原当量胞质-线粒体转移的神经元和星形胶质细胞穿梭机制：当前证据和药理学工具。
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9
CONTROL OF GLUTAMATE OXIDATION IN BRAIN AND LIVER MITOCHONDRIAL SYSTEMS.脑和肝线粒体系统中谷氨酸氧化的调控
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10
The intracellular localization of enzymes in white-adipose-tissue fat-cells and permeability properties of fat-cell mitochondria. Transfer of acetyl units and reducing power between mitochondria and cytoplasm.白色脂肪组织脂肪细胞中酶的细胞内定位及脂肪细胞线粒体的通透性。线粒体与细胞质之间乙酰基单位和还原能力的转移。
Biochem J. 1970 May;117(5):861-77. doi: 10.1042/bj1170861.

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The Malate-Aspartate Shuttle supports thermogenic lipid mobilization in brown adipocytes.苹果酸-天冬氨酸穿梭支持棕色脂肪细胞中的产热脂质动员。
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Kynurenic Acid Acts as a Signaling Molecule Regulating Energy Expenditure and Is Closely Associated With Metabolic Diseases.犬尿酸作为一种信号分子调节能量消耗，与代谢性疾病密切相关。
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The malate-aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway.苹果酸-天冬氨酸穿梭（巴斯德循环）：它是如何诞生并发展成为一种主要代谢途径的。
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Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity.病态肥胖患者皮下和内脏脂肪组织中的线粒体呼吸。
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7
The Effect of Exogenous Nicotinamide Adenine Dinucleotide on the Oxidation of Nicotinamide Adenine Dinucleotide-linked Substrates by Isolated Plant Mitochondria.外源烟酰胺腺嘌呤二核苷酸对分离植物线粒体氧化烟酰胺腺嘌呤二核苷酸连接底物的影响。
Plant Physiol. 1974 Sep;54(3):360-3. doi: 10.1104/pp.54.3.360.
8
Lactic acidosis, neurological deterioration and compromised cellular pyruvate oxidation due to a defect in the reoxidation of cytoplasmically generated NADH.乳酸酸中毒、神经功能恶化以及由于细胞质中生成的NADH再氧化缺陷导致的细胞丙酮酸氧化受损。
Eur J Pediatr. 1983 Apr;140(2):98-101. doi: 10.1007/BF00441651.
9
Rat adipocyte utilization of different substrates: effects of cell size and the control of lipogenesis.大鼠脂肪细胞对不同底物的利用：细胞大小的影响及脂肪生成的调控
Lipids. 1982 Sep;17(9):626-33. doi: 10.1007/BF02535369.
10
The molecular basis for the two different clinical presentations of classical pyruvate carboxylase deficiency.经典型丙酮酸羧化酶缺乏症两种不同临床表现的分子基础。
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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Phosphorylation coupled to oxidation of dihydrodiphosphopyridine nucleotide.磷酸化与二氢二磷酸吡啶核苷酸的氧化相偶联。
J Biol Chem. 1951 May;190(1):345-59.
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The relation between intra- and extramitochondrial pyridine nucleotides.线粒体内外吡啶核苷酸之间的关系。
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INFLUENCE OF THYROID HORMONES ON L-ALPHA-GLYCEROPHOSPHATE DEHYDROGENASES AND OTHER DEHYDROGENASES IN VARIOUS ORGANS OF THE RAT.甲状腺激素对大鼠各器官中L-α-甘油磷酸脱氢酶及其他脱氢酶的影响
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METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS.分离脂肪细胞的代谢。I. 激素对葡萄糖代谢和脂肪分解的影响。
J Biol Chem. 1964 Feb;239:375-80.
6
KINETIC STUDIES OF GLUTAMIC OXALOACETIC TRANSAMINASE ISOZYMES.谷氨酸草酰乙酸转氨酶同工酶的动力学研究
Biochemistry. 1964 Mar;3:338-45. doi: 10.1021/bi00891a007.
7
STUDIES ON THE METABOLISM OF ADIPOSE TISSUE. XV. AN EVALUATION OF THE MAJOR PATHWAYS OF GLUCOSE CATABOLISM AS INFLUENCED BY INSULIN AND EPINEPHRINE.脂肪组织代谢的研究。十五。胰岛素和肾上腺素对葡萄糖分解主要途径的影响评估。
J Biol Chem. 1964 Mar;239:675-85.
8
The aerobic oxidation of reduced diphosphopyridine nucleotide formed by glycolysis in Ehrlich ascites-tumour cells.由糖酵解在艾氏腹水癌细胞中形成的还原型二磷酸吡啶核苷酸的需氧氧化。
Biochim Biophys Acta. 1962 Feb 26;57:270-82. doi: 10.1016/0006-3002(62)91120-4.
9
Steady state equilibria of some DPN-linked reactions and the oxidation/reduction state of the DPN/DPNH system in the cytoplasmatic compartment of liver cells in vivo.体内肝细胞胞质区室中一些与二磷酸吡啶核苷酸（DPN）相关反应的稳态平衡以及DPN/二磷酸吡啶核苷酸还原型（DPNH）系统的氧化/还原状态
Biochem Biophys Res Commun. 1961 Mar 10;4:159-62. doi: 10.1016/0006-291x(61)90262-5.
10
An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study.与肝线粒体外膜相关的电子传递系统。一项生化与形态学研究。
J Cell Biol. 1967 Feb;32(2):415-38. doi: 10.1083/jcb.32.2.415.

还原型烟酰胺腺嘌呤二核苷酸转运至大鼠白色脂肪组织线粒体的过程。

Transport of reduced nicotinamide-adenine dinucleotide into mitochondria of rat white adipose tissue.

作者信息

Robinson B H, Halperin M L

出版信息

Biochem J. 1970 Jan;116(2):229-33. doi: 10.1042/bj1160229.

DOI:10.1042/bj1160229
PMID:4313114
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1185350/
Abstract

Mitochondria from rat white adipose tissue were prepared, exhibiting good respiratory control and P/O ratios. They would not oxidize NADH unless NNN'N'-tetramethyl-p-phenylenediamine was added as a carrier of reducing equivalents. These mitochondria were found to oxidize neither l-glycerol 3-phosphate nor l-glutamate plus l-malate at significant rates. The activity of aspartate aminotransferase in these mitochondria was found to be low compared with that found in rat liver mitochondria. As a consequence of this, the adipose-tissue mitochondria exhibited very low rates of cytoplasmic NADH oxidation in a reconstituted Borst (1962) cycle compared with liver mitochondria.

摘要

制备了来自大鼠白色脂肪组织的线粒体，其表现出良好的呼吸控制和P/O比值。除非添加NNN'N'-四甲基对苯二胺作为还原当量的载体，否则它们不会氧化NADH。发现这些线粒体既不能以显著速率氧化3-磷酸甘油，也不能氧化谷氨酸加苹果酸。与大鼠肝脏线粒体相比，发现这些线粒体中天冬氨酸转氨酶的活性较低。因此，与肝脏线粒体相比，在重构的博斯特（1962年）循环中，脂肪组织线粒体的细胞质NADH氧化速率非常低。