Spear P G, Roizman B
Proc Natl Acad Sci U S A. 1970 Jul;66(3):730-7. doi: 10.1073/pnas.66.3.730.
The membrane glycoproteins specified by herpes simplex virus are synthesized concurrently with structural viral proteins and accumulate in the cytoplasm and in the membranes lining it. Analyses of free and membranebound polyribosomes, the cytoplasmic pool of soluble proteins, and purified smooth membranes showed that viral membrane proteins bind to membranes soon after synthesis and become glycosylated in situ.
单纯疱疹病毒所特有的膜糖蛋白与病毒结构蛋白同时合成,并积聚在细胞质及其衬里的膜中。对游离和膜结合多核糖体、可溶性蛋白质的细胞质池以及纯化的光滑膜的分析表明,病毒膜蛋白在合成后不久就与膜结合,并在原位进行糖基化。